ID   SID3_AJECA              Reviewed;         439 AA.
AC   B2KWI2;
DT   20-JUN-2018, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Hydroxyornithine transacylase SID3 {ECO:0000303|PubMed:18404210};
DE            EC=2.3.1.- {ECO:0000305|PubMed:18404210};
DE   AltName: Full=Siderophore biosynthesis cluster protein SID3 {ECO:0000303|PubMed:18404210};
GN   Name=SID3 {ECO:0000303|PubMed:18404210};
OS   Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=5037;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION.
RC   STRAIN=ATCC 26032 / G217B;
RX   PubMed=18404210; DOI=10.1371/journal.ppat.1000044;
RA   Hwang L.H., Mayfield J.A., Rine J., Sil A.;
RT   "Histoplasma requires SID1, a member of an iron-regulated siderophore gene
RT   cluster, for host colonization.";
RL   PLoS Pathog. 4:E1000044-E1000044(2008).
RN   [2]
RP   INDUCTION.
RC   STRAIN=ATCC 26032 / G217B;
RX   PubMed=18549241; DOI=10.1021/bi800066s;
RA   Chao L.Y., Marletta M.A., Rine J.;
RT   "Sre1, an iron-modulated GATA DNA-binding protein of iron-uptake genes in
RT   the fungal pathogen Histoplasma capsulatum.";
RL   Biochemistry 47:7274-7283(2008).
RN   [3]
RP   INDUCTION.
RX   PubMed=22117028; DOI=10.1128/ec.05274-11;
RA   Hwang L.H., Seth E., Gilmore S.A., Sil A.;
RT   "SRE1 regulates iron-dependent and -independent pathways in the fungal
RT   pathogen Histoplasma capsulatum.";
RL   Eukaryot. Cell 11:16-25(2012).
CC   -!- FUNCTION: Hydroxyornithine transacylase; part of the gene cluster that
CC       mediates the biosynthesis of hydroxamate-containing siderophores that
CC       play a critical role in virulence via intracellular iron acquisition
CC       during macrophage infection (PubMed:18404210).
CC       {ECO:0000269|PubMed:18404210}.
CC   -!- PATHWAY: Siderophore biosynthesis. {ECO:0000305|PubMed:18404210}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q4WF55}.
CC       Note=Targeted to peroxisomes via its PTS1-type peroxisomal targeting
CC       signal (By similarity). {ECO:0000250|UniProtKB:Q4WF55}.
CC   -!- INDUCTION: Expression is induced during iron deprivation and is
CC       regulated by the transcription factor SRE1 (PubMed:18404210,
CC       PubMed:22117028). {ECO:0000269|PubMed:18404210,
CC       ECO:0000269|PubMed:22117028}.
CC   -!- SIMILARITY: Belongs to the lysine N-acyltransferase mbtK family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EU253977; ACC64455.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2KWI2; -.
DR   SMR; B2KWI2; -.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019290; P:siderophore biosynthetic process; IEA:InterPro.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR019432; Acyltransferase_MbtK/IucB-like.
DR   SMART; SM01006; AlcB; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Peroxisome; Transferase.
FT   CHAIN           1..439
FT                   /note="Hydroxyornithine transacylase SID3"
FT                   /id="PRO_0000444394"
FT   MOTIF           437..439
FT                   /note="PTS1-type peroxisomal targeting signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q4WF55"
SQ   SEQUENCE   439 AA;  49903 MW;  62E8CFB909390861 CRC64;
     MSSSREMRDL PLVRLPEPYK TKYELYQASS GPNGRIFQLR LSSDQNNGAI SPPDLLHHQM
     LYFSELIPGP QATLPAESDN TAWARACRSL VSFVTWDGES APTVGQIWML VYAIFSLRPS
     EESFRLSLSG AQKDQLYAEC NAAGLSTRFP TPVQPQPLYT TIEDVVVSRA AFWQGAGSPL
     GTRPAWLVPS ISGSARKLPS EYPAFPLQYT LTSQLTNRPV HTQHPVRPAK PARGAPIYSR
     YIPHLDEFFA MDHLDYTNET HLQLFHTWQN DPRVAVNWKE AGTLDQHREY LRKIDEDPHQ
     IAVLARFNNT YFAYFEIYWA KEDHMGTYYP ALDWDRGRHS LVGDARFRGP HRAMAWWTSL
     IHYIFLDEPR TTCVVGEPKA TNGPVLGYDA AHGFHVHKWG DLPHKRSAMV RCERVRFFEV
     VNFGNVTSNG TAKPSKSKL