ID   SIEA_BPP22              Reviewed;         164 AA.
AC   Q38674; Q7PCH6;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 70.
DE   RecName: Full=Superinfection exclusion protein A;
GN   Name=sieA;
OS   Salmonella phage P22 (Bacteriophage P22).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Podoviridae; Lederbergvirus.
OX   NCBI_TaxID=10754;
OH   NCBI_TaxID=90371; Salmonella typhimurium.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=7768804; DOI=10.1128/jb.177.11.3080-3086.1995;
RA   Hofer B., Ruge M., Dreiseikelmann B.;
RT   "The superinfection exclusion gene (sieA) of bacteriophage P22:
RT   identification and overexpression of the gene and localization of the gene
RT   product.";
RL   J. Bacteriol. 177:3080-3086(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11053393; DOI=10.1128/jb.182.22.6472-6481.2000;
RA   Vander Byl C.S., Kropinski A.M.B.;
RT   "Sequence of the genome of Salmonella bacteriophage P22.";
RL   J. Bacteriol. 182:6472-6481(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12562822; DOI=10.1128/jb.185.4.1475-1477.2003;
RA   Pedulla M.L., Ford M.E., Karthikeyan T., Houtz J.M., Hendrix R.W.,
RA   Hatfull G.F., Poteete A.R., Gilcrease E.B., Winn-Stapley D.A.,
RA   Casjens S.R.;
RT   "Corrected sequence of the bacteriophage P22 genome.";
RL   J. Bacteriol. 185:1475-1477(2003).
CC   -!- FUNCTION: Probably blocks the subsequent transfer of the phage DNA
CC       across the inner membrane into the cytoplasm. By this means, P22
CC       excludes superinfection by the phages of the same family and also
CC       against DNA coming from oter phages. {ECO:0000303|PubMed:7768804}.
CC   -!- SUBCELLULAR LOCATION: Host cell inner membrane
CC       {ECO:0000269|PubMed:7768804}; Multi-pass membrane protein
CC       {ECO:0000305}.
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DR   EMBL; L19603; AAC37339.1; -; Genomic_DNA.
DR   EMBL; AF217253; AAF75056.1; -; Genomic_DNA.
DR   EMBL; BK000583; DAA00996.1; -; Genomic_DNA.
DR   PIR; A57265; A57265.
DR   RefSeq; NP_059639.1; NC_002371.2.
DR   SMR; Q38674; -.
DR   GeneID; 1262788; -.
DR   KEGG; vg:1262788; -.
DR   Proteomes; UP000001795; Genome.
DR   Proteomes; UP000007960; Genome.
DR   GO; GO:0033644; C:host cell membrane; IDA:CACAO.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Host cell inner membrane; Host cell membrane; Host membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..164
FT                   /note="Superinfection exclusion protein A"
FT                   /id="PRO_0000077737"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   164 AA;  18701 MW;  F1AB9F17D7899C57 CRC64;
     MSDSMSYAVL VAATLFLGIG LQIAWLFFSN FIKRKRLESR ISEVSIAIGK NAKNPENEAY
     VLNYLKEKFS PERFENRITD ALGLIISVIH IPLSLLITVW YFAMIAGRIF GFMNIEPVVL
     WVPMILQLLL SIAIFIFSVF IKIVFGRYPG EANGFNKEFI KTIK