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SIFAR_DROME
ID   SIFAR_DROME             Reviewed;         758 AA.
AC   Q8IN35; Q7YU49;
DT   11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 2.
DT   03-AUG-2022, entry version 155.
DE   RecName: Full=Neuropeptide SIFamide receptor {ECO:0000303|PubMed:16378592};
GN   Name=SIFaR {ECO:0000312|FlyBase:FBgn0038880};
GN   Synonyms=SIFR {ECO:0000312|FlyBase:FBgn0038880};
GN   ORFNames=CG10823 {ECO:0000312|FlyBase:FBgn0038880};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN   [1] {ECO:0000312|EMBL:ABB96223.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=16378592; DOI=10.1016/j.bbrc.2005.12.062;
RA   Jorgensen L.M., Hauser F., Cazzamali G., Williamson M.,
RA   Grimmelikhuijzen C.J.;
RT   "Molecular identification of the first SIFamide receptor.";
RL   Biochem. Biophys. Res. Commun. 340:696-701(2006).
RN   [2] {ECO:0000312|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3] {ECO:0000312|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000312|EMBL:AAQ22457.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley {ECO:0000312|EMBL:AAQ22457.1};
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAQ22457.1};
RA   Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA   Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.,
RA   Gonzalez M., Guarin H., Kronmiller B., Li P., Liao G., Miranda A.,
RA   Mungall C.J., Nunoo J., Pacleb J., Paragas V., Park S., Patel S.,
RA   Phouanenavong S., Wan K., Yu C., Lewis S.E., Rubin G.M., Celniker S.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000305}
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=24658384; DOI=10.14348/molcells.2014.2371;
RA   Park S., Sonn J.Y., Oh Y., Lim C., Choe J.;
RT   "SIFamide and SIFamide receptor defines a novel neuropeptide signaling to
RT   promote sleep in Drosophila.";
RL   Mol. Cells 37:295-301(2014).
RN   [6] {ECO:0000305}
RP   FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=26469541; DOI=10.1016/j.peptides.2015.10.003;
RA   Sellami A., Veenstra J.A.;
RT   "SIFamide acts on fruitless neurons to modulate sexual behavior in
RT   Drosophila melanogaster.";
RL   Peptides 74:50-56(2015).
CC   -!- FUNCTION: Receptor for the neuropeptide SIFamide (PubMed:16378592).
CC       Modulates sexual behavior by playing a role in male sex discrimination
CC       (PubMed:26469541). Also involved in promoting sleep (PubMed:24658384).
CC       {ECO:0000269|PubMed:16378592, ECO:0000269|PubMed:24658384,
CC       ECO:0000269|PubMed:26469541}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: In the larva, expressed in a bilateral pair of
CC       neurons in each of the abdominal rhabdomeres. In the adult, expressed
CC       predominantly in the central nervous system with expression also
CC       detected in two neurons in the uterus. {ECO:0000269|PubMed:26469541}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown causes a significant
CC       reduction in total sleep amount (PubMed:24658384). It also causes
CC       significant male-male courtship behavior although a number of flies
CC       appear to behave normally (PubMed:26469541).
CC       {ECO:0000269|PubMed:24658384, ECO:0000269|PubMed:26469541}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|RuleBase:RU000688}.
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DR   EMBL; DQ285411; ABB96223.1; -; mRNA.
DR   EMBL; AE014297; AAN13859.2; -; Genomic_DNA.
DR   EMBL; AE014297; ACZ94970.1; -; Genomic_DNA.
DR   EMBL; BT009988; AAQ22457.1; -; mRNA.
DR   RefSeq; NP_001163674.1; NM_001170203.1.
DR   RefSeq; NP_650966.2; NM_142709.2.
DR   AlphaFoldDB; Q8IN35; -.
DR   SMR; Q8IN35; -.
DR   IntAct; Q8IN35; 2.
DR   STRING; 7227.FBpp0291029; -.
DR   GlyGen; Q8IN35; 3 sites.
DR   PaxDb; Q8IN35; -.
DR   DNASU; 42530; -.
DR   EnsemblMetazoa; FBtr0084098; FBpp0083497; FBgn0038880.
DR   EnsemblMetazoa; FBtr0301815; FBpp0291029; FBgn0038880.
DR   GeneID; 42530; -.
DR   KEGG; dme:Dmel_CG10823; -.
DR   UCSC; CG10823-RA; d. melanogaster.
DR   CTD; 42530; -.
DR   FlyBase; FBgn0038880; SIFaR.
DR   VEuPathDB; VectorBase:FBgn0038880; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01020000230390; -.
DR   HOGENOM; CLU_018892_0_0_1; -.
DR   InParanoid; Q8IN35; -.
DR   OMA; PQFLCQE; -.
DR   OrthoDB; 830221at2759; -.
DR   PhylomeDB; Q8IN35; -.
DR   Reactome; R-DME-416476; G alpha (q) signalling events.
DR   BioGRID-ORCS; 42530; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 42530; -.
DR   PRO; PR:Q8IN35; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0038880; Expressed in brain and 4 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
DR   GO; GO:0005887; C:integral component of plasma membrane; IDA:FlyBase.
DR   GO; GO:0008528; F:G protein-coupled peptide receptor activity; ISS:FlyBase.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; ISS:FlyBase.
DR   GO; GO:0008188; F:neuropeptide receptor activity; IPI:FlyBase.
DR   GO; GO:0004983; F:neuropeptide Y receptor activity; IEA:InterPro.
DR   GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR   GO; GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:FlyBase.
DR   GO; GO:0048047; P:mating behavior, sex discrimination; IMP:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA:FlyBase.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000611; NPY_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01012; NRPEPTIDEYR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Behavior; Cell membrane; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..758
FT                   /note="Neuropeptide SIFamide receptor"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000436207"
FT   TOPO_DOM        1..104
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        105..125
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        126..212
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..254
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        255..275
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        276..282
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        283..303
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        304..323
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        324..344
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        345..386
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        387..407
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        408..436
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        437..457
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        458..758
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          532..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        57
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        97
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   758 AA;  83442 MW;  A2E3BC8D566E009B CRC64;
     MMAASGRIRK RKHKSHTSGD VPSTTTSVPM PIPTMAPGKM VAETMEEAAA LAGDYNNFTH
     NFVDLQNLLS FNELNGTSGS GGTAVSSLGS SSAIKLNNSA ITDTLLGTVL TTATATVAPA
     ASSLLATLAA TTTASARGSL AGKSLAIADA TSSTYYSNLL NLSPATTSLI SAAAATKSYN
     DSALRWEQLD GSVDFGFDPL YRHSLAMSMV YCVAYIVVFL VGLIGNSFVI AVVLRAPRMR
     TVTNYFIVNL AIADILVIVF CLPATLIGNI FVPWMLGWLM CKFVPYIQGV SVAASVYSLI
     AVSLDRFIAI WWPLKQMTKR RARIMIIGIW VIALVTTIPW LLFFDLVPAE EVFSDALVSA
     YSQPQFLCQE VWPPGTDGNL YFLLANLVAC YLLPMSLITL CYVLIWIKVS TRSIPGESKD
     AQMDRMQQKS KVKVIKMLVA VVILFVLSWL PLYVIFARIK FGSDISQEEF EILKKVMPVA
     QWLGSSNSCI NPILYSVNKK YRRGFAAIIK SRSCCGRLRY YDNVAIASST TSTRKSSHYH
     QNSSRKSPSS KGNAVSYIYE HNSLRRHNMM LKQDSNLSQQ MLLKQDSHGS RQFLIKQESS
     CSDASGIRRP LCQQDSNGSK VSLSKQDSIV SYMEARRSAG HGLNDTLVDR DSVSMDVGRR
     QGATPSSLLD KRQKFVKQDS VISFVDQRPE QRRHQLVKQD SVISFADQRR GLLHKQDSLM
     ANRTGDAPTH HVSILKKTDS QLSYGSSTSP RRNADLYE
 
 
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