ID   SIFA_AGRIP              Reviewed;          70 AA.
AC   C0HKV8;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2018, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Neuropeptide SIFamide {ECO:0000303|PubMed:29466015};
DE            Short=SIFa {ECO:0000303|PubMed:29466015};
DE   AltName: Full=TYRKPPFNGSIF-amide {ECO:0000305};
DE   Flags: Precursor;
OS   Agrotis ipsilon (Black cutworm moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Noctuinae; Noctuini; Agrotis.
OX   NCBI_TaxID=56364;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 23-34, TISSUE SPECIFICITY,
RP   MASS SPECTROMETRY, IDENTIFICATION BY MASS SPECTROMETRY, AND AMIDATION AT
RP   PHE-34.
RX   PubMed=29466015; DOI=10.1021/acs.jproteome.7b00779;
RA   Diesner M., Gallot A., Binz H., Gaertner C., Vitecek S., Kahnt J.,
RA   Schachtner J., Jacquin-Joly E., Gadenne C.;
RT   "Mating-induced differential peptidomics of neuropeptides and protein
RT   hormones in Agrotis ipsilon moths.";
RL   J. Proteome Res. 17:1397-1414(2018).
CC   -!- FUNCTION: Ligand for the neuropeptide SIFamide receptor.
CC       {ECO:0000250|UniProtKB:Q6IGX9}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in antennal lobe (AL) and gnathal
CC       ganglion (GNG) with expression detected in most animals (at protein
CC       level). Not expressed in corpora cardiaca (CC) and corpora allata (CA)
CC       (at protein level). {ECO:0000269|PubMed:29466015}.
CC   -!- MASS SPECTROMETRY: Mass=1425.77; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:29466015};
CC   -!- SIMILARITY: Belongs to the FARP (FMRFamide related peptide) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; C0HKV8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..34
FT                   /note="Neuropeptide SIFamide"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444274"
FT   PROPEP          38..70
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444275"
FT   MOD_RES         34
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:29466015"
SQ   SEQUENCE   70 AA;  7862 MW;  5D4ADE9EE5225750 CRC64;
     MRFIVALCLF AIVMCIIHKA EGTYRKPPFN GSIFGKRGVV EYDTTGRALS ALCEIASETC
     QAWYQTLENK