SIFB_SALTY
ID SIFB_SALTY Reviewed; 316 AA.
AC Q9KIB9; Q7CQI0;
DT 09-FEB-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Secreted effector protein SifB;
GN Name=sifB; OrderedLocusNames=STM1602;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SECRETION VIA TYPE III SECRETION
RP SYSTEM.
RC STRAIN=ATCC 14028s / SGSG 2262;
RX PubMed=10861017; DOI=10.1073/pnas.97.13.7539;
RA Miao E.A., Miller S.I.;
RT "A conserved amino acid sequence directing intracellular type III secretion
RT by Salmonella typhimurium.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:7539-7544(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
RN [3]
RP SUBCELLULAR LOCATION, AND SECRETION VIA TYPE III SECRETION SYSTEM.
RC STRAIN=ATCC 14028s / SGSG 2262;
RX PubMed=12496192; DOI=10.1128/iai.71.1.418-427.2003;
RA Freeman J.A., Ohl M.E., Miller S.I.;
RT "The Salmonella enterica serovar typhimurium translocated effectors SseJ
RT and SifB are targeted to the Salmonella-containing vacuole.";
RL Infect. Immun. 71:418-427(2003).
CC -!- FUNCTION: Effector proteins function to alter host cell physiology and
CC promote bacterial survival in host tissues. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12496192}. Host
CC cytoplasm {ECO:0000269|PubMed:12496192}. Note=Secreted via type III
CC secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm.
CC Localizes to the Salmonella-containing vacuole (SCV) at early time
CC points following invasion and subsequently traffics away from the SCV
CC along Salmonella-induced filaments (Sifs) in epithelial cells.
CC -!- SIMILARITY: Belongs to the Sif family. {ECO:0000305}.
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DR EMBL; AF236076; AAF82084.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20520.1; -; Genomic_DNA.
DR RefSeq; NP_460561.1; NC_003197.2.
DR RefSeq; WP_001122926.1; NC_003197.2.
DR AlphaFoldDB; Q9KIB9; -.
DR SMR; Q9KIB9; -.
DR STRING; 99287.STM1602; -.
DR PaxDb; Q9KIB9; -.
DR EnsemblBacteria; AAL20520; AAL20520; STM1602.
DR GeneID; 1253120; -.
DR KEGG; stm:STM1602; -.
DR PATRIC; fig|99287.12.peg.1693; -.
DR HOGENOM; CLU_826077_0_0_6; -.
DR OMA; KNEAHYQ; -.
DR PhylomeDB; Q9KIB9; -.
DR BioCyc; SENT99287:STM1602-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR010637; Sif.
DR Pfam; PF06767; Sif; 1.
PE 3: Inferred from homology;
KW Host cytoplasm; Reference proteome; Secreted; Virulence.
FT CHAIN 1..316
FT /note="Secreted effector protein SifB"
FT /id="PRO_0000391466"
SQ SEQUENCE 316 AA; 35908 MW; 12F8F63130A41EA3 CRC64;
MPITIGRGFL KSEMFSQSAI SQRSFFTLLW EKIKDFFCDT QRSTADQYIK ELCDVASPPD
AQRLFDLFCK LYELSSPSCR GNFHFQHYKD AECQYTNLCI KDGEDIPLCI MIRQDHYYYE
IMNRTVLCVD TQSAHLKRYS DINIKASTYV CEPLCCLFPE RLQLSLSGGI TFSVDLKNIE
ETLIAMAEKG NLCDWKEQER KAAISSRINL GIAQAGVTAI DDAIKNKIAA KVIENTNLKN
AAFEPNYAQS SVTQIVYSCL FKNEILMNML EESSSHGLLC LNELTEYVAL QVHNSLFSED
LSSLVETTKN EAHHQS
