BH084_ARATH
ID BH084_ARATH Reviewed; 328 AA.
AC Q7XHI9; A0MEL3; O80976;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transcription factor bHLH84;
DE AltName: Full=Basic helix-loop-helix protein 84;
DE Short=AtbHLH84;
DE Short=bHLH 84;
DE AltName: Full=bHLH transcription factor bHLH084;
GN Name=BHLH84; OrderedLocusNames=At2g14760; ORFNames=F26C24.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- INTERACTION:
CC Q7XHI9; Q9LV17: BHLH79; NbExp=3; IntAct=EBI-15194255, EBI-15191993;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7XHI9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7XHI9-2; Sequence=VSP_036092, VSP_036093;
CC -!- SIMILARITY: Belongs to the bHLH protein family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC24181.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=ABK28492.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AJ577584; CAE12171.1; -; mRNA.
DR EMBL; AC004705; AAC24181.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06331.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06332.1; -; Genomic_DNA.
DR EMBL; DQ446497; ABE65812.1; -; mRNA.
DR EMBL; DQ652985; ABK28492.1; ALT_SEQ; mRNA.
DR PIR; T02600; T02600.
DR RefSeq; NP_001118318.1; NM_001124846.2. [Q7XHI9-2]
DR RefSeq; NP_179083.2; NM_127040.4. [Q7XHI9-1]
DR AlphaFoldDB; Q7XHI9; -.
DR BioGRID; 1323; 10.
DR IntAct; Q7XHI9; 10.
DR STRING; 3702.AT2G14760.3; -.
DR PaxDb; Q7XHI9; -.
DR PRIDE; Q7XHI9; -.
DR EnsemblPlants; AT2G14760.1; AT2G14760.1; AT2G14760. [Q7XHI9-1]
DR EnsemblPlants; AT2G14760.2; AT2G14760.2; AT2G14760. [Q7XHI9-2]
DR GeneID; 815964; -.
DR Gramene; AT2G14760.1; AT2G14760.1; AT2G14760. [Q7XHI9-1]
DR Gramene; AT2G14760.2; AT2G14760.2; AT2G14760. [Q7XHI9-2]
DR KEGG; ath:AT2G14760; -.
DR Araport; AT2G14760; -.
DR eggNOG; ENOG502R684; Eukaryota.
DR HOGENOM; CLU_066110_1_0_1; -.
DR InParanoid; Q7XHI9; -.
DR OMA; PCESSKK; -.
DR PhylomeDB; Q7XHI9; -.
DR PRO; PR:Q7XHI9; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q7XHI9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..328
FT /note="Transcription factor bHLH84"
FT /id="PRO_0000358776"
FT DOMAIN 243..292
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 145..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 254..257
FT /note="KRRE -> VIYT (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_036092"
FT VAR_SEQ 258..328
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_036093"
SQ SEQUENCE 328 AA; 36500 MW; D11EF5C3741ED6D2 CRC64;
MEAMGEWSTG LGGIYTEEAD FMNQLLASYE QPCGGSSSET TATLTAYHHQ GSQWNGGFCF
SQESSSYSGY CAAMPRQEED NNGMEDATIN TNLYLVGEET SECDATEYSG KSLLPLETVA
ENHDHSMLQP ENSLTTTTDE KMFNQCESSK KRTRATTTDK NKRANKARRS QKCVEMSGEN
ENSGEEEYTE KAAGKRKTKP LKPQKTCCSD DESNGGDTFL SKEDGEDSKA LNLNGKTRAS
RGAATDPQSL YARKRRERIN ERLRILQHLV PNGTKVDIST MLEEAVQYVK FLQLQIKLLS
SDDLWMYAPI AYNGMDIGLD LKLNALTR
