ID   SIG1S_REOVD             Reviewed;         120 AA.
AC   P03529; Q85669;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   12-AUG-2020, entry version 50.
DE   RecName: Full=Protein sigma-1-small;
DE            Short=Sigma1s;
DE   AltName: Full=Sigma-s;
DE   AltName: Full=Sigma1NS;
DE   AltName: Full=Sigma1bNS;
DE   AltName: Full=p14;
GN   Name=S1;
OS   Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Orthoreovirus.
OX   NCBI_TaxID=10886;
OH   NCBI_TaxID=40674; Mammalia.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=4000269; DOI=10.1038/315421a0;
RA   Bassel-Duby R., Jayasuriya A.K., Chatterjee D., Sonenberg N.,
RA   Maizel J.V. Jr., Fields B.N.;
RT   "Sequence of reovirus haemagglutinin predicts a coiled-coil structure.";
RL   Nature 315:421-423(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=6095208; DOI=10.1093/nar/12.22.8699;
RA   Nagata L., Masri S.A., Mah D.C.W., Lee P.W.K.;
RT   "Molecular cloning and sequencing of the reovirus (serotype 3) S1 gene
RT   which encodes the viral cell attachment protein sigma 1.";
RL   Nucleic Acids Res. 12:8699-8710(1984).
CC   -!- SIMILARITY: Belongs to the orthoreovirus sigma-1s protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X01161; CAA25606.1; -; Genomic_RNA.
DR   PIR; A04128; QQXRS3.
DR   GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR003478; Capsid_sigma_1s.
DR   Pfam; PF02454; Sigma_1s; 1.
PE   3: Inferred from homology;
KW   Host G2/M cell cycle arrest by virus; Host-virus interaction;
KW   Modulation of host cell cycle by virus.
FT   CHAIN           1..120
FT                   /note="Protein sigma-1-small"
FT                   /id="PRO_0000222755"
FT   CONFLICT        3
FT                   /note="Y -> H (in Ref. 2; CAA25606)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        99
FT                   /note="S -> T (in Ref. 2; CAA25606)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   120 AA;  14017 MW;  AC152A19E80E47E4 CRC64;
     MEYHCQKGLN QGSRRSRRRL KYTLILSSGS PRDSMMQTNE SSLLSKVGMT WLHQSVMLNL
     QSPDWKALSE PSKQLSMDLI RVLPSWVLEW DNLRQDLQSY ALITTISLRE WILQNVTLDH