ID   SIG1S_REOVL             Reviewed;         119 AA.
AC   P07938;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   23-FEB-2022, entry version 63.
DE   RecName: Full=Protein sigma-1-small;
DE            Short=Sigma1s;
DE   AltName: Full=Sigma-s;
DE   AltName: Full=Sigma1NS;
DE   AltName: Full=Sigma1bNS;
DE   AltName: Full=p14;
GN   Name=S1;
OS   Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Orthoreovirus.
OX   NCBI_TaxID=10884;
OH   NCBI_TaxID=40674; Mammalia.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3855545; DOI=10.1073/pnas.82.1.24;
RA   Cashdollar L.W., Chmelo R.A., Wiener J.R., Joklik W.K.;
RT   "Sequences of the S1 genes of the three serotypes of reovirus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:24-28(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2430568; DOI=10.1016/0006-291x(86)90761-8;
RA   Munemitsu S.M., Atwater J.A., Samuel C.E.;
RT   "Biosynthesis of reovirus-specified polypeptides. Molecular cDNA cloning
RT   and nucleotide sequence of the reovirus serotype 1 Lang strain bicistronic
RT   s1 mRNA which encodes the minor capsid polypeptide sigma 1a and the
RT   nonstructural polypeptide sigma 1bNS.";
RL   Biochem. Biophys. Res. Commun. 140:508-514(1986).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2335823; DOI=10.1128/jvi.64.6.2976-2989.1990;
RA   Nibert M.L., Dermody T.S., Fields B.N.;
RT   "Structure of the reovirus cell-attachment protein: a model for the domain
RT   organization of sigma 1.";
RL   J. Virol. 64:2976-2989(1990).
CC   -!- SIMILARITY: Belongs to the orthoreovirus sigma-1s protein family.
CC       {ECO:0000305}.
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DR   EMBL; M10260; AAA66878.1; -; Genomic_RNA.
DR   EMBL; M14779; AAA47277.1; -; Genomic_RNA.
DR   EMBL; M35963; AAA47243.1; -; Genomic_RNA.
DR   PIR; B26436; MNXR1B.
DR   PIR; B34829; B34829.
DR   SMR; P07938; -.
DR   Proteomes; UP000007253; Genome.
DR   GO; GO:0039592; P:suppression by virus of G2/M transition of host mitotic cell cycle; IEA:UniProtKB-KW.
DR   InterPro; IPR003478; Capsid_sigma_1s.
DR   Pfam; PF02454; Sigma_1s; 1.
PE   3: Inferred from homology;
KW   Host G2/M cell cycle arrest by virus; Host-virus interaction;
KW   Modulation of host cell cycle by virus; Reference proteome.
FT   CHAIN           1..119
FT                   /note="Protein sigma-1-small"
FT                   /id="PRO_0000222757"
FT   CONFLICT        71
FT                   /note="V -> L (in Ref. 2; AAA47243)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   119 AA;  13989 MW;  D6EEE53353BC6190 CRC64;
     MAPSQKKSRK SRNKSRSTLM ISGLPILNST DLEDRLLTSA IASQPLSQDW VRWIIDLWVS
     RVRSRNYLTQ VARTLRAYPH WVTESMLSNH ELTVWIRSRL ISLDEHPLWR QMLEAYGQN