ID   SIG1_CRIDS              Reviewed;          10 AA.
AC   P86123;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   11-DEC-2019, entry version 9.
DE   RecName: Full=Signiferin-1 {ECO:0000303|PubMed:18601958};
OS   Crinia deserticola (Desert froglet).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Myobatrachoidea; Myobatrachidae;
OC   Myobatrachinae; Crinia.
OX   NCBI_TaxID=104060;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP   DISULFIDE BOND, AND DISCUSSION OF SEQUENCE.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:18601958};
RX   PubMed=18601958; DOI=10.1016/j.regpep.2008.06.004;
RA   Jackway R.J., Pukala T.L., Maselli V.M., Musgrave I.F., Bowie J.H., Liu Y.,
RA   Surinya-Johnson K.H., Donnellan S.C., Doyle J.R., Llewellyn L.E.,
RA   Tyler M.J.;
RT   "Disulfide-containing peptides from the glandular skin secretions of
RT   froglets of the genus Crinia: structure, activity and evolutionary
RT   trends.";
RL   Regul. Pept. 151:80-87(2008).
CC   -!- FUNCTION: Induces mouse splenocyte proliferation and guinea pig smooth
CC       muscle contraction through binding to CCK-BR.
CC       {ECO:0000269|PubMed:18601958}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18601958}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:18601958}.
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DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0070665; P:positive regulation of leukocyte proliferation; IDA:UniProtKB.
DR   GO; GO:0045987; P:positive regulation of smooth muscle contraction; IDA:UniProtKB.
DR   GO; GO:0042311; P:vasodilation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing; Disulfide bond;
KW   Growth factor; Secreted; Vasoactive; Vasodilator.
FT   PEPTIDE         1..10
FT                   /note="Signiferin-1"
FT                   /evidence="ECO:0000269|PubMed:18601958"
FT                   /id="PRO_0000371738"
FT   DISULFID        3..10
FT                   /evidence="ECO:0000269|PubMed:18601958"
SQ   SEQUENCE   10 AA;  1191 MW;  9F9CFA504B47605E CRC64;
     RLCIPYIIPC