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SIGA_CHLPN
ID   SIGA_CHLPN              Reviewed;         572 AA.
AC   Q9Z7F0; Q9JQE8; Q9K1S3;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 148.
DE   RecName: Full=RNA polymerase sigma factor SigA {ECO:0000255|HAMAP-Rule:MF_00963};
DE   AltName: Full=Sigma-66;
DE   AltName: Full=Sigma-70 {ECO:0000255|HAMAP-Rule:MF_00963};
DE   AltName: Full=Sigma-A;
GN   Name=sigA {ECO:0000255|HAMAP-Rule:MF_00963}; Synonyms=rpoD;
GN   OrderedLocusNames=CPn_0756, CP_1116, CpB0784;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. This sigma factor is the primary sigma factor during
CC       exponential growth. {ECO:0000255|HAMAP-Rule:MF_00963}.
CC   -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic core.
CC       {ECO:0000255|HAMAP-Rule:MF_00963}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00963}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00963}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF38883.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE001363; AAD18894.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF38883.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000008; BAA98964.1; -; Genomic_DNA.
DR   EMBL; AE009440; AAP98713.1; -; Genomic_DNA.
DR   PIR; B86585; B86585.
DR   PIR; E72039; E72039.
DR   PIR; E81502; E81502.
DR   RefSeq; NP_224951.1; NC_000922.1.
DR   RefSeq; WP_010883393.1; NZ_LN847257.1.
DR   AlphaFoldDB; Q9Z7F0; -.
DR   SMR; Q9Z7F0; -.
DR   STRING; 115711.CP_1116; -.
DR   PRIDE; Q9Z7F0; -.
DR   EnsemblBacteria; AAD18894; AAD18894; CPn_0756.
DR   EnsemblBacteria; AAF38883; AAF38883; CP_1116.
DR   GeneID; 45050811; -.
DR   KEGG; cpa:CP_1116; -.
DR   KEGG; cpj:rpoD; -.
DR   KEGG; cpn:CPn_0756; -.
DR   KEGG; cpt:CpB0784; -.
DR   PATRIC; fig|115713.3.peg.833; -.
DR   eggNOG; COG0568; Bacteria.
DR   HOGENOM; CLU_014793_7_2_0; -.
DR   OrthoDB; 1565734at2; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.10; -; 2.
DR   Gene3D; 1.10.220.120; -; 1.
DR   HAMAP; MF_00963; Sigma70_RpoD_SigA; 1.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000943; RNA_pol_sigma70.
DR   InterPro; IPR009042; RNA_pol_sigma70_r1_2.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR007624; RNA_pol_sigma70_r3.
DR   InterPro; IPR007630; RNA_pol_sigma70_r4.
DR   InterPro; IPR007127; RNA_pol_sigma_70_r1_1.
DR   InterPro; IPR042189; RNA_pol_sigma_70_r1_1_sf.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR012760; RNA_pol_sigma_RpoD_C.
DR   InterPro; IPR028630; Sigma70_RpoD.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03979; Sigma70_r1_1; 1.
DR   Pfam; PF00140; Sigma70_r1_2; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF04539; Sigma70_r3; 1.
DR   Pfam; PF04545; Sigma70_r4; 1.
DR   PRINTS; PR00046; SIGMA70FCT.
DR   SUPFAM; SSF88659; SSF88659; 2.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02393; RpoD_Cterm; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS00715; SIGMA70_1; 1.
DR   PROSITE; PS00716; SIGMA70_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Sigma factor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..572
FT                   /note="RNA polymerase sigma factor SigA"
FT                   /id="PRO_0000093882"
FT   DNA_BIND        515..534
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   REGION          321..391
FT                   /note="Sigma-70 factor domain-2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   REGION          400..476
FT                   /note="Sigma-70 factor domain-3"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   REGION          489..542
FT                   /note="Sigma-70 factor domain-4"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00963"
FT   MOTIF           345..348
FT                   /note="Interaction with polymerase core subunit RpoC"
SQ   SEQUENCE   572 AA;  66306 MW;  5FE7B6471AC68F11 CRC64;
     MFMNTQNSQA TEVSSEEESQ KKLEELVALA KEQGFITYEE INEILPMSFD TPEQIDQVLI
     FLTGMDIQVL NQIDVERQKE KKKEAKELEG LARRTEGTPD DPVRMYLKEM GTVPLLTREE
     EVEISKRIEK AQVQIERIIL RFRYSAKEAI SIAHYLISGK ERFDKIISEK EVEDKTHFLK
     LLPKLITLLK EEDTYLENLL LSLKQPDLSK QEAAKLNDSL EKCRIRTQAY LRCFHCRHNV
     TEDFGEVVFK AYDSFLHLEQ QINDLKVRAE RNKFAAAKLA AAKRKLYKRE VAAGRTLEEF
     KKDVRMLQRW MDKSQEAKKE MVESNLRLVI SIAKKYTNRG LSFLDLIQEG NMGLMKAVEK
     FEYRRGYKFS TYATWWIRQA VTRAIADQAR TIRIPVHMIE TINKVLRGAK KLMMETGKEP
     TPEELAEELG LTPDRVREIY KIAQHPISLQ AEVGEGSESS FGDFLEDTAV ESPAEATGYS
     MLKDKMKEVL KTLTDRERFV LIHRFGLLDG KPKTLEEVGS AFNVTRERIR QIEAKALRKM
     RHPIRSKQLR AFLDLLEEEK TGTSKVKSLK SK
 
 
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