SIGC_ARVS1
ID SIGC_ARVS1 Reviewed; 326 AA.
AC Q992I2; Q84141;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 02-JUN-2021, entry version 66.
DE RecName: Full=Sigma-C capsid protein;
DE AltName: Full=Sigma-3 protein;
GN ORFNames=ORF3;
OS Avian reovirus (strain S1133) (ARV).
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC Reovirales; Reoviridae; Spinareovirinae; Orthoreovirus.
OX NCBI_TaxID=38171;
OH NCBI_TaxID=9031; Gallus gallus (Chicken).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=7782781; DOI=10.1099/0022-1317-76-6-1515;
RA Shapouri M.R., Kane M., Letarte M., Bergeron J., Arella M., Silim A.;
RT "Cloning, sequencing and expression of the S1 gene of avian reovirus.";
RL J. Gen. Virol. 76:1515-1520(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=11883183; DOI=10.1006/viro.2001.1159;
RA Bodelon G., Labrada L., Martinez-Costas J., Benavente J.;
RT "The avian reovirus genome segment S1 is a functionally tricistronic gene
RT that expresses one structural and two nonstructural proteins in infected
RT cells.";
RL Virology 290:181-191(2001).
RN [3]
RP CHARACTERIZATION.
RX PubMed=11752709; DOI=10.1099/0022-1317-83-1-131;
RA Grande A., Costas C., Benavente J.;
RT "Subunit composition and conformational stability of the oligomeric form of
RT the avian reovirus cell-attachment protein sigmaC.";
RL J. Gen. Virol. 83:131-139(2002).
RN [4]
RP FUNCTION.
RX PubMed=15033566; DOI=10.1016/j.virol.2003.12.004;
RA Shih W.L., Hsu H.W., Liao M.H., Lee L.H., Liu H.J.;
RT "Avian reovirus sigmaC protein induces apoptosis in cultured cells.";
RL Virology 321:65-74(2004).
CC -!- FUNCTION: Structural protein responsible for cell attachment. Induces
CC cell apoptosis. {ECO:0000269|PubMed:15033566}.
CC -!- SUBUNIT: Homotrimer.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- DOMAIN: The C-terminus is important for the induction of cellular
CC apoptosis.
CC -!- SIMILARITY: Belongs to the orthoreovirus sigma C protein family.
CC {ECO:0000305}.
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DR EMBL; L39002; AAC42113.1; -; Genomic_RNA.
DR EMBL; AF330703; AAK18188.1; -; Genomic_RNA.
DR PDB; 2BSF; X-ray; 2.10 A; A=151-326.
DR PDB; 2BT7; X-ray; 2.35 A; A=157-326.
DR PDB; 2BT8; X-ray; 3.00 A; A=157-326.
DR PDB; 2JJL; X-ray; 2.30 A; A=117-326.
DR PDB; 2VRS; X-ray; 1.75 A; A/B/C=117-326.
DR PDBsum; 2BSF; -.
DR PDBsum; 2BT7; -.
DR PDBsum; 2BT8; -.
DR PDBsum; 2JJL; -.
DR PDBsum; 2VRS; -.
DR SMR; Q992I2; -.
DR EvolutionaryTrace; Q992I2; -.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR InterPro; IPR041345; Reo_sigmaC_M.
DR InterPro; IPR007662; SigmaC_C.
DR Pfam; PF04582; Reo_sigmaC; 1.
DR Pfam; PF17750; Reo_sigmaC_M; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Apoptosis; Capsid protein; Coiled coil;
KW Host-virus interaction; Viral attachment to host cell; Virion;
KW Virus entry into host cell.
FT CHAIN 1..326
FT /note="Sigma-C capsid protein"
FT /id="PRO_0000222758"
FT COILED 60..80
FT /evidence="ECO:0000255"
FT CONFLICT 57
FT /note="T -> S (in Ref. 1; AAC42113)"
FT /evidence="ECO:0000305"
FT CONFLICT 97
FT /note="S -> P (in Ref. 1; AAC42113)"
FT /evidence="ECO:0000305"
FT CONFLICT 162
FT /note="F -> L (in Ref. 1; AAC42113)"
FT /evidence="ECO:0000305"
FT CONFLICT 193
FT /note="A -> E (in Ref. 1; AAC42113)"
FT /evidence="ECO:0000305"
FT CONFLICT 204
FT /note="A -> E (in Ref. 1; AAC42113)"
FT /evidence="ECO:0000305"
FT CONFLICT 221
FT /note="H -> Y (in Ref. 1; AAC42113)"
FT /evidence="ECO:0000305"
FT HELIX 118..121
FT /evidence="ECO:0007829|PDB:2VRS"
FT HELIX 123..153
FT /evidence="ECO:0007829|PDB:2VRS"
FT TURN 156..159
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 166..169
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 172..175
FT /evidence="ECO:0007829|PDB:2VRS"
FT TURN 179..181
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 182..190
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 196..209
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 213..223
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 226..239
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 241..249
FT /evidence="ECO:0007829|PDB:2VRS"
FT HELIX 250..252
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 253..255
FT /evidence="ECO:0007829|PDB:2VRS"
FT HELIX 260..263
FT /evidence="ECO:0007829|PDB:2VRS"
FT HELIX 267..270
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 274..282
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 285..297
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 300..306
FT /evidence="ECO:0007829|PDB:2VRS"
FT STRAND 308..325
FT /evidence="ECO:0007829|PDB:2VRS"
SQ SEQUENCE 326 AA; 34856 MW; 7E2A0D3ADDEAC153 CRC64;
MAGLNPSQRR EVVSLILSLT SNVNISHGDL TPIYERLTNL EASTELLHRS ISDISTTVSN
ISANLQDMTH TLDDVTANLD GLRTTVTALQ DSVSILSTNV TDLTNRSSAH AAILSSLQTT
VDGNSTAISN LKSDISSNGL AITDLQDRVK SLESTASHGL SFSPPLSVAD GVVSLDMDPY
FCSQRVSLTS YSAEAQLMQF RWMARGTNGS SDTIDMTVNA HCHGRRTDYM MSSTGNLTVT
SNVVLLTFDL SDITHIPSDL ARLVPSAGFQ AASFPVDVSF TRDSATHAYQ AYGVYSSSRV
FTITFPTGGD GTANIRSLTV RTGIDT
