ID   SIGD_DICDI              Reviewed;         445 AA.
AC   Q6TU45; Q55FT2;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Probable spore coat protein sigD;
DE   AltName: Full=SrfA-induced gene D protein;
DE   Flags: Precursor;
GN   Name=sigD; ORFNames=DDB_G0267474;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND INDUCTION.
RC   STRAIN=AX4;
RX   PubMed=14665466; DOI=10.1128/ec.2.6.1327-1335.2003;
RA   Escalante R., Moreno N., Sastre L.;
RT   "Dictyostelium discoideum developmentally regulated genes whose expression
RT   is dependent on MADS box transcription factor SrfA.";
RL   Eukaryot. Cell 2:1327-1335(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   DEVELOPMENTAL STAGE, AND INDUCTION BY SRFA.
RX   PubMed=15075287; DOI=10.1128/ec.3.2.564-566.2004;
RA   Escalante R., Iranfar N., Sastre L., Loomis W.F.;
RT   "Identification of genes dependent on the MADS box transcription factor
RT   SrfA in Dictyostelium discoideum development.";
RL   Eukaryot. Cell 3:564-566(2004).
CC   -!- FUNCTION: May contribute to the structure of the coat at the interface
CC       between the middle, cellulosic layer and the outer, electron-dense,
CC       proteinaceous layer. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at late stage of development (20 to 24
CC       hours). {ECO:0000269|PubMed:14665466, ECO:0000269|PubMed:15075287}.
CC   -!- INDUCTION: By cAMP and the MADS-box protein srfA.
CC       {ECO:0000269|PubMed:14665466, ECO:0000269|PubMed:15075287}.
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DR   EMBL; AY387647; AAQ95661.1; -; Genomic_DNA.
DR   EMBL; AAFI02000003; EAL73190.1; -; Genomic_DNA.
DR   RefSeq; XP_647451.1; XM_642359.1.
DR   AlphaFoldDB; Q6TU45; -.
DR   STRING; 44689.DDB0191296; -.
DR   PaxDb; Q6TU45; -.
DR   EnsemblProtists; EAL73190; EAL73190; DDB_G0267474.
DR   GeneID; 8616258; -.
DR   KEGG; ddi:DDB_G0267474; -.
DR   dictyBase; DDB_G0267474; sigD.
DR   HOGENOM; CLU_615989_0_0_1; -.
DR   InParanoid; Q6TU45; -.
DR   PhylomeDB; Q6TU45; -.
DR   PRO; PR:Q6TU45; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0031160; C:spore wall; IEA:UniProt.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   InterPro; IPR007643; Dict_spore_N.
DR   InterPro; IPR003645; Fol_N.
DR   Pfam; PF04562; Dicty_spore_N; 1.
DR   SMART; SM00274; FOLN; 6.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Signal; Sporulation.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..445
FT                   /note="Probable spore coat protein sigD"
FT                   /id="PRO_0000346778"
FT   DOMAIN          21..139
FT                   /note="DSCP-N"
FT   DOMAIN          178..201
FT                   /note="Follistatin-like 1"
FT   DOMAIN          213..237
FT                   /note="Follistatin-like 2"
FT   DOMAIN          272..295
FT                   /note="Follistatin-like 3"
FT   DOMAIN          324..348
FT                   /note="Follistatin-like 4"
FT   DOMAIN          368..391
FT                   /note="Follistatin-like 5"
FT   DOMAIN          416..439
FT                   /note="Follistatin-like 6"
FT   REGION          141..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   445 AA;  47051 MW;  183698FA5E564C89 CRC64;
     MKKVITLLAL MAAAQIYAQG QECINLSENE CHRNSSCVPV NFKKCCGDQQ FACYEGDFNS
     CHYITKCYKS SKSLDVIEST NECYIPPAGY ELFEPVSSCT NDELKHCSDQ GKQCIFKRND
     CPNPTSCCPG HGVCEDFNRS ESGSGNKEQI STTGNTGPQT RGFTISGTGG TGSVPIDACT
     NVLCQQGEHC EVDQDGRAHC YVNIESIGTL PLGCLNVVCQ PHQHCEIDKE SGLAHCVLDI
     NPIGFTTIDA SSTVAGSSST TGGSGGTGSN DICSNVHCPD NYHCEMRQDG KAQCVADINA
     IGFTTSGAST NGLIPPASTG WSDVCSNVIC PPGYYCQKNE QTGKADCLNY SSSTTGGGTG
     STTGSIDVCS NVICPPYFHC EKNDKGWAQC AADINAIGFS TSSTNGLVST TGSNDVCQNV
     HCPQFFKCEK NENGLGECVS TLIPL