BH094_ARATH
ID BH094_ARATH Reviewed; 304 AA.
AC Q9SK91; Q8L9T3;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Transcription factor bHLH94;
DE AltName: Full=Basic helix-loop-helix protein 94;
DE Short=AtbHLH94;
DE Short=bHLH 94;
DE AltName: Full=Transcription factor EN 16;
DE AltName: Full=bHLH transcription factor bHLH094;
GN Name=BHLH94; Synonyms=EN16; OrderedLocusNames=At1g22490; ORFNames=F12K8.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 10-304, TISSUE SPECIFICITY, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- INTERACTION:
CC Q9SK91; Q9FG01: ATO; NbExp=3; IntAct=EBI-15192173, EBI-4475455;
CC Q9SK91; P46639: KNAT1; NbExp=3; IntAct=EBI-15192173, EBI-530486;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems,
CC and flowers. {ECO:0000269|PubMed:12679534}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF18528.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM65775.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC006551; AAF18528.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30247.1; -; Genomic_DNA.
DR EMBL; AY088234; AAM65775.1; ALT_FRAME; mRNA.
DR EMBL; AF488622; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; B86358; B86358.
DR RefSeq; NP_564171.1; NM_102098.3.
DR AlphaFoldDB; Q9SK91; -.
DR SMR; Q9SK91; -.
DR BioGRID; 24094; 33.
DR IntAct; Q9SK91; 30.
DR STRING; 3702.AT1G22490.1; -.
DR iPTMnet; Q9SK91; -.
DR PaxDb; Q9SK91; -.
DR ProteomicsDB; 240836; -.
DR EnsemblPlants; AT1G22490.1; AT1G22490.1; AT1G22490.
DR GeneID; 838855; -.
DR Gramene; AT1G22490.1; AT1G22490.1; AT1G22490.
DR KEGG; ath:AT1G22490; -.
DR Araport; AT1G22490; -.
DR TAIR; locus:2009537; AT1G22490.
DR eggNOG; ENOG502QSWD; Eukaryota.
DR HOGENOM; CLU_044652_1_0_1; -.
DR InParanoid; Q9SK91; -.
DR OMA; AIDMESH; -.
DR PhylomeDB; Q9SK91; -.
DR PRO; PR:Q9SK91; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SK91; baseline and differential.
DR Genevisible; Q9SK91; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..304
FT /note="Transcription factor bHLH94"
FT /id="PRO_0000358785"
FT DOMAIN 112..163
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 86..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 188
FT /note="S -> I (in Ref. 3; AAM65775)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 304 AA; 34893 MW; CD3038E75540CEE0 CRC64;
MPLEAVVYPQ DPFGYLSNCK DFMFHDLYSQ EEFVAQDTKN NIDKLGHEQS FVEQGKEDDH
QWRDYHQYPL LIPSLGEELG LTAIDVESHP PPQHRRKRRR TRNCKNKEEI ENQRMTHIAV
ERNRRKQMNE YLAVLRSLMP SSYAQRGDQA SIVGGAINYV KELEHILQSM EPKRTRTHDP
KGDKTSTSSL VGPFTDFFSF PQYSTKSSSD VPESSSSPAE IEVTVAESHA NIKIMTKKKP
RQLLKLITSL QSLRLTLLHL NVTTLHNSIL YSISVRVEEG SQLNTVDDIA TALNQTIRRI
QEET
