ID   SIGE_SALTY              Reviewed;         113 AA.
AC   O30917; Q7CQS7;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Chaperone protein SigE;
GN   Name=sigE; Synonyms=pipC; OrderedLocusNames=STM1090;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND REGULATION BY SIRA.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=9537377; DOI=10.1128/jb.180.7.1793-1802.1998;
RA   Hong K.H., Miller V.L.;
RT   "Identification of a novel Salmonella invasion locus homologous to Shigella
RT   ipgDE.";
RL   J. Bacteriol. 180:1793-1802(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [3]
RP   REGULATION BY INVF AND SICA.
RC   STRAIN=ATCC 14028s / SGSG 2262, LT2, and SL1344;
RX   PubMed=10692170; DOI=10.1046/j.1365-2958.2000.01772.x;
RA   Darwin K.H., Miller V.L.;
RT   "The putative invasion protein chaperone SicA acts together with InvF to
RT   activate the expression of Salmonella typhimurium virulence genes.";
RL   Mol. Microbiol. 35:949-960(2000).
RN   [4]
RP   FUNCTION.
RC   STRAIN=ATCC 14028s / SGSG 2262;
RX   PubMed=11157959; DOI=10.1128/jb.183.4.1452-1454.2001;
RA   Darwin K.H., Robinson L.S., Miller V.L.;
RT   "SigE is a chaperone for the Salmonella enterica serovar Typhimurium
RT   invasion protein SigD.";
RL   J. Bacteriol. 183:1452-1454(2001).
RN   [5]
RP   X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
RX   PubMed=11685226; DOI=10.1038/nsb717;
RA   Luo Y., Bertero M.G., Frey E.A., Pfuetzner R.A., Wenk M.R., Creagh L.,
RA   Marcus S.L., Lim D., Sicheri F., Kay C., Haynes C., Finlay B.B.,
RA   Strynadka N.C.J.;
RT   "Structural and biochemical characterization of the type III secretion
RT   chaperones CesT and SigE.";
RL   Nat. Struct. Biol. 8:1031-1036(2001).
CC   -!- FUNCTION: Molecular chaperone required for SopB/SigD stabilization and
CC       secretion. {ECO:0000269|PubMed:11157959, ECO:0000269|PubMed:9537377}.
CC   -!- SUBUNIT: Homodimer or higher-order oligomers.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Transcriptionally regulated by InvF and SicA. Also regulated
CC       by SirA.
CC   -!- SIMILARITY: Belongs to the IpgE/SigE chaperone family. {ECO:0000305}.
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DR   EMBL; AF021817; AAC46235.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL20022.1; -; Genomic_DNA.
DR   RefSeq; NP_460063.1; NC_003197.2.
DR   RefSeq; WP_000444724.1; NC_003197.2.
DR   PDB; 1K3S; X-ray; 1.90 A; A/B=1-113.
DR   PDBsum; 1K3S; -.
DR   AlphaFoldDB; O30917; -.
DR   SMR; O30917; -.
DR   STRING; 99287.STM1090; -.
DR   PaxDb; O30917; -.
DR   EnsemblBacteria; AAL20022; AAL20022; STM1090.
DR   GeneID; 1252608; -.
DR   KEGG; stm:STM1090; -.
DR   PATRIC; fig|99287.12.peg.1154; -.
DR   HOGENOM; CLU_2131737_0_0_6; -.
DR   OMA; DDEIQVY; -.
DR   BioCyc; SENT99287:STM1090-MON; -.
DR   EvolutionaryTrace; O30917; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   CDD; cd17022; T3SC_IA_SigE-like; 1.
DR   InterPro; IPR013095; T3SS_chaperone.
DR   Pfam; PF07824; Chaperone_III; 1.
DR   PIRSF; PIRSF034754; T3SS_chaperone; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chaperone; Cytoplasm; Reference proteome; Virulence.
FT   CHAIN           1..113
FT                   /note="Chaperone protein SigE"
FT                   /id="PRO_0000160575"
FT   HELIX           4..11
FT                   /evidence="ECO:0007829|PDB:1K3S"
FT   STRAND          24..26
FT                   /evidence="ECO:0007829|PDB:1K3S"
FT   STRAND          29..35
FT                   /evidence="ECO:0007829|PDB:1K3S"
FT   STRAND          37..48
FT                   /evidence="ECO:0007829|PDB:1K3S"
FT   HELIX           53..65
FT                   /evidence="ECO:0007829|PDB:1K3S"
FT   STRAND          66..72
FT                   /evidence="ECO:0007829|PDB:1K3S"
FT   STRAND          78..86
FT                   /evidence="ECO:0007829|PDB:1K3S"
FT   HELIX           91..112
FT                   /evidence="ECO:0007829|PDB:1K3S"
SQ   SEQUENCE   113 AA;  12751 MW;  34DEE3AB3944560E CRC64;
     MESLLNRLYD ALGLDAPEDE PLLIIDDGIQ VYFNESDHTL EMCCPFMPLP DDILTLQHFL
     RLNYTSAVTI GADADNTALV ALYRLPQTST EEEALTGFEL FISNVKQLKE HYA