ID   SIGF_DICDI              Reviewed;         231 AA.
AC   Q6TMK2; Q54GR6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=SrfA-induced gene F protein;
GN   Name=sigF; ORFNames=DDB_G0289885;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND INDUCTION BY
RP   SRFA.
RX   PubMed=15075287; DOI=10.1128/ec.3.2.564-566.2004;
RA   Escalante R., Iranfar N., Sastre L., Loomis W.F.;
RT   "Identification of genes dependent on the MADS box transcription factor
RT   SrfA in Dictyostelium discoideum development.";
RL   Eukaryot. Cell 3:564-566(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [3]
RP   INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=17517120; DOI=10.1186/1471-2164-8-123;
RA   Na J., Tunggal B., Eichinger L.;
RT   "STATc is a key regulator of the transcriptional response to hyperosmotic
RT   shock.";
RL   BMC Genomics 8:123-123(2007).
RN   [4]
RP   DEVELOPMENTAL STAGE, AND INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=17950724; DOI=10.1016/j.ydbio.2007.08.055;
RA   Prabhu Y., Mondal S., Eichinger L., Noegel A.A.;
RT   "A GPCR involved in post aggregation events in Dictyostelium discoideum.";
RL   Dev. Biol. 312:29-43(2007).
CC   -!- DEVELOPMENTAL STAGE: Expressed late in development.
CC       {ECO:0000269|PubMed:15075287, ECO:0000269|PubMed:17950724}.
CC   -!- INDUCTION: Induced by srfA, during development. Down-regulated in grlA
CC       null-cells at 16 hours of starvation. {ECO:0000269|PubMed:15075287,
CC       ECO:0000269|PubMed:17517120, ECO:0000269|PubMed:17950724}.
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DR   EMBL; AY392431; AAQ98873.1; -; Genomic_DNA.
DR   EMBL; AAFI02000149; EAL62455.1; -; Genomic_DNA.
DR   RefSeq; XP_636003.1; XM_630911.1.
DR   AlphaFoldDB; Q6TMK2; -.
DR   STRING; 44689.DDB0191278; -.
DR   PaxDb; Q6TMK2; -.
DR   EnsemblProtists; EAL62455; EAL62455; DDB_G0289885.
DR   GeneID; 8627418; -.
DR   KEGG; ddi:DDB_G0289885; -.
DR   dictyBase; DDB_G0289885; sigF.
DR   eggNOG; ENOG502R8A8; Eukaryota.
DR   HOGENOM; CLU_1201724_0_0_1; -.
DR   InParanoid; Q6TMK2; -.
DR   OMA; NIPLANY; -.
DR   PRO; PR:Q6TMK2; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0006972; P:hyperosmotic response; IEP:dictyBase.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   SUPFAM; SSF54427; SSF54427; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..231
FT                   /note="SrfA-induced gene F protein"
FT                   /id="PRO_0000330367"
SQ   SEQUENCE   231 AA;  26846 MW;  C7222565A6B291B4 CRC64;
     MVEINDIIKL YTVHPNLDLI DKNFAEDCEF EAFNIPSFKV KGIEAIHEIF KAIGFYAKDI
     KISKYNYTHS SHCIVLNTQQ EITFNILPFV KFNYRMIINI HKNKENKITK FEEITDLESV
     IQNIPLANYG YFNIIKPALG YLMVKAGSYN RGFQNNGPNK IQATMERLSD NFVEKKEVNY
     SEPLIKLSKN FNGVTHQDKI DNMDEELFNS KKIDIKDGSN NAWKKPLNLH Q