SIGG_DICDI
ID SIGG_DICDI Reviewed; 425 AA.
AC Q54GL3; Q6TMK5;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=SrfA-induced gene G protein;
GN Name=sigG; ORFNames=DDB_G0290071;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND INDUCTION BY
RP SRFA.
RX PubMed=15075287; DOI=10.1128/ec.3.2.564-566.2004;
RA Escalante R., Iranfar N., Sastre L., Loomis W.F.;
RT "Identification of genes dependent on the MADS box transcription factor
RT SrfA in Dictyostelium discoideum development.";
RL Eukaryot. Cell 3:564-566(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=17517120; DOI=10.1186/1471-2164-8-123;
RA Na J., Tunggal B., Eichinger L.;
RT "STATc is a key regulator of the transcriptional response to hyperosmotic
RT shock.";
RL BMC Genomics 8:123-123(2007).
RN [4]
RP DEVELOPMENTAL STAGE, AND INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=17950724; DOI=10.1016/j.ydbio.2007.08.055;
RA Prabhu Y., Mondal S., Eichinger L., Noegel A.A.;
RT "A GPCR involved in post aggregation events in Dictyostelium discoideum.";
RL Dev. Biol. 312:29-43(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed late in development.
CC {ECO:0000269|PubMed:15075287, ECO:0000269|PubMed:17950724}.
CC -!- INDUCTION: Induced by srfA, during development. Down-regulated in grlA
CC null-cells at 16 hours of starvation. Rapidly up-regulated by
CC hyperosmotic stress, which is dependent on dstC. Shows early
CC transcriptional response to sorbitol exposure.
CC {ECO:0000269|PubMed:15075287, ECO:0000269|PubMed:17517120,
CC ECO:0000269|PubMed:17950724}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY392428; AAQ98870.1; -; Genomic_DNA.
DR EMBL; AAFI02000152; EAL62396.1; -; Genomic_DNA.
DR RefSeq; XP_635904.1; XM_630812.1.
DR AlphaFoldDB; Q54GL3; -.
DR SMR; Q54GL3; -.
DR STRING; 44689.DDB0191392; -.
DR PaxDb; Q54GL3; -.
DR PRIDE; Q54GL3; -.
DR EnsemblProtists; EAL62396; EAL62396; DDB_G0290071.
DR GeneID; 8627470; -.
DR KEGG; ddi:DDB_G0290071; -.
DR dictyBase; DDB_G0290071; sigG.
DR HOGENOM; CLU_646293_0_0_1; -.
DR OMA; QTMPAGH; -.
DR PRO; PR:Q54GL3; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Coiled coil; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..425
FT /note="SrfA-induced gene G protein"
FT /id="PRO_0000391760"
FT TRANSMEM 91..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 393..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 41..91
FT /evidence="ECO:0000255"
FT COILED 172..208
FT /evidence="ECO:0000255"
FT COILED 292..340
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 28
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 188
FT /note="Q -> H (in Ref. 1; AAQ98870)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 425 AA; 50280 MW; 83B80D4B8C09E12B CRC64;
MSTPTRTKKL IVSPTSVRKR VQNQNLTNTT YSTNSNSSRY RDSEENFLNR QQQELKQLHD
QQLYELQELQ EQQINEIEEL SKQRSNTRIR NVFKVLITIL VGSIIYGTYT NQFQPNPIEP
FHLTEPIGQT WLHSLKDIST NWYHIWSDSF KDLARIKPLS ESQTMPAGHR LHEKQILEKT
LRRHQQEQDN NNNNKKTIEN QMERMKRTDL ERAIKEKTFF LDPTHYVNEE MIKQEIERQL
KPHPGAPTPY NKDVYNSQNI YYPSSDAIPM VREKIENLEN KVLDSVDEAI YKFGQKSKEL
LHNIQEKKEQ IKEKLNDEPS NIEKEFNSLI KEIEKANYNI FKDLKDNYGE PTIEKLNELR
YKFNDAARES REVIKNKIES AQAIEQELAK NLKKPHADSN GHPKPYPHHH LLNQENQIDE
NLIIV
