SIGIR_RAT
ID SIGIR_RAT Reviewed; 409 AA.
AC Q4V892;
DT 27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Single Ig IL-1-related receptor;
DE AltName: Full=Single Ig IL-1R-related molecule;
DE AltName: Full=Single immunoglobulin domain-containing IL1R-related protein;
DE AltName: Full=Toll/interleukin-1 receptor 8;
DE Short=TIR8;
GN Name=Sigirr;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a negative regulator of the Toll-like and IL-1R
CC receptor signaling pathways. Attenuates the recruitment of receptor-
CC proximal signaling components to the TLR4 receptor, probably through an
CC TIR-TIR domain interaction with TLR4. Through its extracellular domain
CC interferes with the heterodimerization of Il1R1 and IL1RAP (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon
CC IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR,
CC MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at
CC least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with
CC PALM3 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000305}.
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DR EMBL; BC097488; AAH97488.1; -; mRNA.
DR RefSeq; NP_001020058.1; NM_001024887.1.
DR RefSeq; XP_006230614.1; XM_006230552.3.
DR RefSeq; XP_006230615.1; XM_006230553.3.
DR RefSeq; XP_008758211.1; XM_008759989.2.
DR RefSeq; XP_008758212.1; XM_008759990.2.
DR RefSeq; XP_017444719.1; XM_017589230.1.
DR AlphaFoldDB; Q4V892; -.
DR SMR; Q4V892; -.
DR IntAct; Q4V892; 1.
DR STRING; 10116.ENSRNOP00000051758; -.
DR GlyGen; Q4V892; 5 sites.
DR PaxDb; Q4V892; -.
DR PRIDE; Q4V892; -.
DR GeneID; 309106; -.
DR KEGG; rno:309106; -.
DR CTD; 59307; -.
DR RGD; 1306732; Sigirr.
DR VEuPathDB; HostDB:ENSRNOG00000015593; -.
DR eggNOG; ENOG502QVF7; Eukaryota.
DR HOGENOM; CLU_040046_0_0_1; -.
DR InParanoid; Q4V892; -.
DR OMA; LEQDWCT; -.
DR OrthoDB; 735868at2759; -.
DR PhylomeDB; Q4V892; -.
DR TreeFam; TF325519; -.
DR PRO; PR:Q4V892; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000015593; Expressed in adult mammalian kidney and 18 other tissues.
DR Genevisible; Q4V892; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISS:HGNC-UCL.
DR GO; GO:0006953; P:acute-phase response; ISS:HGNC-UCL.
DR GO; GO:0032682; P:negative regulation of chemokine production; ISS:HGNC-UCL.
DR GO; GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; ISS:HGNC-UCL.
DR GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; ISS:HGNC-UCL.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.40.50.10140; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890; PTHR11890; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF52200; SSF52200; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..409
FT /note="Single Ig IL-1-related receptor"
FT /id="PRO_0000099067"
FT TOPO_DOM 1..118
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 140..409
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 9..109
FT /note="Ig-like C2-type"
FT DOMAIN 162..306
FT /note="TIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT MOD_RES 382
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JLZ8"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 73
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 85
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 32..97
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 409 AA; 46171 MW; 9BC31BF94AE43091 CRC64;
MAGVCDRVPN FLSPSEDQAL GPALGSAVAL NCTAWVFSRP QCPQPSVQWL KDGLALGNGS
HFSLHQDFWV SDNFSEIVSS VLVFNLTKAE DYGTFTCSAW NVSSHSFTLW RAGPAGHVAA
VLASLLVLVV LLLVALLYVK CRLNVLLWYQ DTYGEVEMND GKLYDAYVSY SDRPEDRKFV
NFILKPQLER RRGYKLFLED RDLLPRAEPS ADLLVNLSRC RRLIVVLSDA FLRRPWCSQS
FREGLCRLLE LTRRPIFITF EGQRREPIHP ALRLLRQHRH LVTLLLWKPG SVTPSSDFWK
ELQLALPRKV QYRPVEGDPQ TRLQDDKDPM LIVRGRAAQG RAMESELDPD PEGDLGVRGP
VFGEPPTPLH ESKVSIGEGH ASEMDVSDLG SRNYSARTDF YCLVSEDDV
