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BH096_ARATH
ID   BH096_ARATH             Reviewed;         320 AA.
AC   Q9C7T4;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Transcription factor bHLH96;
DE   AltName: Full=Basic helix-loop-helix protein 96;
DE            Short=AtbHLH96;
DE            Short=bHLH 96;
DE   AltName: Full=Transcription factor EN 15;
DE   AltName: Full=bHLH transcription factor bHLH096;
GN   Name=BHLH96; Synonyms=EN15; OrderedLocusNames=At1g72210; ORFNames=T9N14.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
RP   NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=12679534; DOI=10.1093/molbev/msg088;
RA   Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT   "The basic helix-loop-helix transcription factor family in plants: a
RT   genome-wide study of protein structure and functional diversity.";
RL   Mol. Biol. Evol. 20:735-747(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=12897250; DOI=10.1105/tpc.013839;
RA   Toledo-Ortiz G., Huq E., Quail P.H.;
RT   "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL   Plant Cell 15:1749-1770(2003).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=14600211; DOI=10.1105/tpc.151140;
RA   Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA   Jakoby M., Werber M., Weisshaar B.;
RT   "Update on the basic helix-loop-helix transcription factor gene family in
RT   Arabidopsis thaliana.";
RL   Plant Cell 15:2497-2502(2003).
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- INTERACTION:
CC       Q9C7T4; F4JI72: At4g03250; NbExp=3; IntAct=EBI-15192637, EBI-15192535;
CC       Q9C7T4; Q58G01: BHLH155; NbExp=3; IntAct=EBI-15192637, EBI-15197899;
CC       Q9C7T4; F4JIJ7: BHLH162; NbExp=4; IntAct=EBI-15192637, EBI-15191643;
CC       Q9C7T4; Q9MAI5: ERF8; NbExp=3; IntAct=EBI-15192637, EBI-2000137;
CC       Q9C7T4; Q9FGM1: PYL8; NbExp=3; IntAct=EBI-15192637, EBI-2429535;
CC       Q9C7T4; Q84MC7: PYL9; NbExp=3; IntAct=EBI-15192637, EBI-2349513;
CC       Q9C7T4; O82277: TCP10; NbExp=4; IntAct=EBI-15192637, EBI-3133327;
CC       Q9C7T4; Q93Z00: TCP14; NbExp=3; IntAct=EBI-15192637, EBI-4424563;
CC       Q9C7T4; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-15192637, EBI-15192325;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, stems,
CC       and flowers. {ECO:0000269|PubMed:12679534}.
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DR   EMBL; AJ459771; CAD30833.1; -; mRNA.
DR   EMBL; AC067754; AAG51804.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE35289.1; -; Genomic_DNA.
DR   EMBL; BT003871; AAO41920.1; -; mRNA.
DR   EMBL; BT006086; AAP04071.1; -; mRNA.
DR   PIR; F96745; F96745.
DR   RefSeq; NP_177366.1; NM_105880.4.
DR   AlphaFoldDB; Q9C7T4; -.
DR   SMR; Q9C7T4; -.
DR   BioGRID; 28773; 62.
DR   IntAct; Q9C7T4; 59.
DR   STRING; 3702.AT1G72210.1; -.
DR   PaxDb; Q9C7T4; -.
DR   PRIDE; Q9C7T4; -.
DR   EnsemblPlants; AT1G72210.1; AT1G72210.1; AT1G72210.
DR   GeneID; 843553; -.
DR   Gramene; AT1G72210.1; AT1G72210.1; AT1G72210.
DR   KEGG; ath:AT1G72210; -.
DR   Araport; AT1G72210; -.
DR   TAIR; locus:2207061; AT1G72210.
DR   eggNOG; ENOG502QSWD; Eukaryota.
DR   HOGENOM; CLU_044652_1_0_1; -.
DR   InParanoid; Q9C7T4; -.
DR   OMA; GFLEDCW; -.
DR   OrthoDB; 1446303at2759; -.
DR   PhylomeDB; Q9C7T4; -.
DR   PRO; PR:Q9C7T4; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9C7T4; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..320
FT                   /note="Transcription factor bHLH96"
FT                   /id="PRO_0000358787"
FT   DOMAIN          122..173
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   DOMAIN          244..320
FT                   /note="ACT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01007"
FT   REGION          30..121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          184..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        191..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   320 AA;  35972 MW;  FCF1F34C1B18D3FB CRC64;
     MALEAVVYPQ DPFSYISCKD FPFYDLYFQE EEDQDPQDTK NNIKLGQGQG HGFASNNYNG
     RTGDYSDDYN YNEEDLQWPR DLPYGSAVDT ESQPPPSDVA AGGGRRKRRR TRSSKNKEEI
     ENQRMTHIAV ERNRRKQMNE YLAVLRSLMP PYYAQRGDQA SIVGGAINYL KELEHHLQSM
     EPPVKTATED TGAGHDQTKT TSASSSGPFS DFFAFPQYSN RPTSAAAAEG MAEIEVTMVE
     SHASLKILAK KRPRQLLKLV SSIQSLRLTL LHLNVTTRDD SVLYSISVKV EEGSQLNTVE
     DIAAAVNQIL RRIEEESSFS
 
 
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