SIGJ_DICDI
ID SIGJ_DICDI Reviewed; 357 AA.
AC Q6TMJ3; Q55CX8;
DT 02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=SrfA-induced gene J protein;
GN Name=sigJ; ORFNames=DDB_G0269254;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND INDUCTION BY
RP SRFA.
RX PubMed=15075287; DOI=10.1128/ec.3.2.564-566.2004;
RA Escalante R., Iranfar N., Sastre L., Loomis W.F.;
RT "Identification of genes dependent on the MADS box transcription factor
RT SrfA in Dictyostelium discoideum development.";
RL Eukaryot. Cell 3:564-566(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION.
RX PubMed=15470253; DOI=10.1128/ec.3.5.1241-1248.2004;
RA Maruo T., Sakamoto H., Iranfar N., Fuller D., Morio T., Urushihara H.,
RA Tanaka Y., Maeda M., Loomis W.F.;
RT "Control of cell type proportioning in Dictyostelium discoideum by
RT differentiation-inducing factor as determined by in situ hybridization.";
RL Eukaryot. Cell 3:1241-1248(2004).
RN [4]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=16469056; DOI=10.1111/j.1462-5822.2005.00633.x;
RA Farbrother P., Wagner C., Na J., Tunggal B., Morio T., Urushihara H.,
RA Tanaka Y., Schleicher M., Steinert M., Eichinger L.;
RT "Dictyostelium transcriptional host cell response upon infection with
RT Legionella.";
RL Cell. Microbiol. 8:438-456(2006).
RN [5]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=17517120; DOI=10.1186/1471-2164-8-123;
RA Na J., Tunggal B., Eichinger L.;
RT "STATc is a key regulator of the transcriptional response to hyperosmotic
RT shock.";
RL BMC Genomics 8:123-123(2007).
RN [6]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed early in development and up-regulated
CC late in development. {ECO:0000269|PubMed:15075287}.
CC -!- INDUCTION: Induced by srfA, during development. Down-regulated by
CC phagocytic stimuli. Up-regulated by Legionella pneumophila infection.
CC Rapidly up-regulated by hyperosmotic stress, which is dependent on
CC dstC. Shows early transcriptional response to sorbitol exposure.
CC {ECO:0000269|PubMed:15075287, ECO:0000269|PubMed:16469056,
CC ECO:0000269|PubMed:17517120, ECO:0000269|PubMed:18559084}.
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DR EMBL; AY392441; AAQ98883.1; -; Genomic_DNA.
DR EMBL; AAFI02000005; EAL71977.1; -; Genomic_DNA.
DR RefSeq; XP_646353.1; XM_641261.1.
DR AlphaFoldDB; Q6TMJ3; -.
DR STRING; 44689.DDB0191111; -.
DR PaxDb; Q6TMJ3; -.
DR EnsemblProtists; EAL71977; EAL71977; DDB_G0269254.
DR GeneID; 8617308; -.
DR KEGG; ddi:DDB_G0269254; -.
DR dictyBase; DDB_G0269254; sigJ.
DR eggNOG; ENOG502RSQD; Eukaryota.
DR HOGENOM; CLU_777124_0_0_1; -.
DR InParanoid; Q6TMJ3; -.
DR OMA; GYYGLHQ; -.
DR PhylomeDB; Q6TMJ3; -.
DR PRO; PR:Q6TMJ3; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006972; P:hyperosmotic response; IEP:dictyBase.
PE 2: Evidence at transcript level;
KW Coiled coil; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..357
FT /note="SrfA-induced gene J protein"
FT /id="PRO_0000391761"
FT TRANSMEM 290..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 5..51
FT /evidence="ECO:0000255"
FT COILED 150..177
FT /evidence="ECO:0000255"
FT COILED 223..270
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 357 AA; 40049 MW; 5E3918268F35B8EC CRC64;
MGRVEDQIKD NYNSLSHEGE RLNREAKIES EKLKNNAKLD AKDMKKDIDE SVHSSWETVK
EGAKTVQDYI SSGIESVKHT ITTEPAQKDM ENLKHNVNHN LEEAEKEGSS VLNNISNFFK
GSAEEAKSEA ERIGYEAYKD GDQFVGDVHK NFKRTANETQ KDANRLTSDV KNESNKIYKD
IKDESNKLYN DVKGESSKIY NGAKKEGSKL ATDLKKDTQY VADETKKMAA DLKNKAADTY
QDLSHDASKK ATQLKKKASE TLDESADAIE HQFDIMKKDF RHLNQRNGMI WGSIGLIGGA
TATSYLFPSA SPMAKFTFIA GLASLGGYYG LHQPHNKIVD NAFHKANNKK EELKKKI
