ID   SIGK_DICDI              Reviewed;         426 AA.
AC   Q6TMJ6; Q55FY2;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=SrfA-induced gene K protein;
DE   Flags: Precursor;
GN   Name=sigK; ORFNames=DDB_G0267476;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND INDUCTION BY
RP   SRFA.
RC   STRAIN=AX4;
RX   PubMed=15075287; DOI=10.1128/ec.3.2.564-566.2004;
RA   Escalante R., Iranfar N., Sastre L., Loomis W.F.;
RT   "Identification of genes dependent on the MADS box transcription factor
RT   SrfA in Dictyostelium discoideum development.";
RL   Eukaryot. Cell 3:564-566(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- DEVELOPMENTAL STAGE: Expressed in stalk cells late in development.
CC       {ECO:0000269|PubMed:15075287}.
CC   -!- INDUCTION: Induced by srfA, during development.
CC       {ECO:0000269|PubMed:15075287}.
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DR   EMBL; AY392438; AAQ98880.1; -; Genomic_DNA.
DR   EMBL; AAFI02000003; EAL73191.1; -; Genomic_DNA.
DR   RefSeq; XP_647401.1; XM_642309.1.
DR   AlphaFoldDB; Q6TMJ6; -.
DR   STRING; 44689.DDB0191495; -.
DR   PaxDb; Q6TMJ6; -.
DR   EnsemblProtists; EAL73191; EAL73191; DDB_G0267476.
DR   GeneID; 8616208; -.
DR   KEGG; ddi:DDB_G0267476; -.
DR   dictyBase; DDB_G0267476; sigK.
DR   eggNOG; ENOG502R14C; Eukaryota.
DR   HOGENOM; CLU_630795_0_0_1; -.
DR   InParanoid; Q6TMJ6; -.
DR   OMA; YTALDYF; -.
DR   PhylomeDB; Q6TMJ6; -.
DR   PRO; PR:Q6TMJ6; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   InterPro; IPR002049; LE_dom.
DR   Pfam; PF00053; Laminin_EGF; 1.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01186; EGF_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Glycoprotein;
KW   Laminin EGF-like domain; Reference proteome; Repeat; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..426
FT                   /note="SrfA-induced gene K protein"
FT                   /id="PRO_0000397675"
FT   DOMAIN          325..348
FT                   /note="Laminin EGF-like 1"
FT   DOMAIN          384..408
FT                   /note="Laminin EGF-like 2"
FT   CARBOHYD        64
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        136
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        160
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        226
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        385
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        330..339
FT                   /evidence="ECO:0000250"
FT   DISULFID        342..358
FT                   /evidence="ECO:0000250"
FT   DISULFID        370..388
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   426 AA;  46615 MW;  558C575F57B3906E CRC64;
     MKKMKILSFF ILSLAIIIGI VYSRQCDDKC KQDYPYSSCN GNLNLYRGLG YDGNGNVIFS
     GKYNSSQGSG GFGLPSIFSV PSSGGCQLSK RFDIQGEILD GPGYTALDYF YKYLPQLDRY
     YVRFNQRGSP IFSIYNQTSN EIKAVFNIFN TPFVPAFSQN ESAPFFVYGG YGIYGLAKYP
     TDRSDAQQAK LIYQSQIVNG LEIDGDQLYM TTYQGQFLKG SLNCLNCTKD QLQLLVTDSE
     LASATSVSGF ALTSDYMYFS YSGGIKGYPK NGDASRVRKL VSENVVAMIS NGDFLYYQTD
     SGVVKSVSTS GNHPQVNILY TPVSDNQCQC SVGFSGDDCR QCDNGMVLWA SDNGIPMCSP
     LNSLGKPKTC YAAYQCGSSP FIICNGTCTC LPGFSGNDCT LCGNGGEVIW ENGYPTCVIQ
     IKKIIT