BH099_ARATH
ID BH099_ARATH Reviewed; 296 AA.
AC Q9FKQ6;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 123.
DE RecName: Full=Transcription factor bHLH99;
DE AltName: Full=Basic helix-loop-helix protein 99;
DE Short=AtbHLH99;
DE Short=bHLH 99;
DE AltName: Full=Transcription factor EN 18;
DE AltName: Full=bHLH transcription factor bHLH099;
GN Name=BHLH99; Synonyms=EN18; OrderedLocusNames=At5g65320; ORFNames=MNA5.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 15-296, TISSUE SPECIFICITY, INDUCTION, GENE
RP FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed constitutively in roots, stems, and
CC flowers. {ECO:0000269|PubMed:12679534}.
CC -!- INDUCTION: Repressed by heat treatment. {ECO:0000269|PubMed:12679534}.
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DR EMBL; AB011479; BAB11554.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98039.1; -; Genomic_DNA.
DR EMBL; AY070095; AAL49832.1; -; mRNA.
DR EMBL; AY096704; AAM20338.1; -; mRNA.
DR EMBL; AF488625; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_201335.1; NM_125930.2.
DR AlphaFoldDB; Q9FKQ6; -.
DR SMR; Q9FKQ6; -.
DR BioGRID; 21899; 4.
DR IntAct; Q9FKQ6; 4.
DR STRING; 3702.AT5G65320.1; -.
DR PaxDb; Q9FKQ6; -.
DR EnsemblPlants; AT5G65320.1; AT5G65320.1; AT5G65320.
DR GeneID; 836657; -.
DR Gramene; AT5G65320.1; AT5G65320.1; AT5G65320.
DR KEGG; ath:AT5G65320; -.
DR Araport; AT5G65320; -.
DR TAIR; locus:2168235; AT5G65320.
DR eggNOG; ENOG502QSWD; Eukaryota.
DR HOGENOM; CLU_044652_5_0_1; -.
DR InParanoid; Q9FKQ6; -.
DR OMA; KVEADCQ; -.
DR OrthoDB; 1201509at2759; -.
DR PhylomeDB; Q9FKQ6; -.
DR PRO; PR:Q9FKQ6; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKQ6; baseline and differential.
DR Genevisible; Q9FKQ6; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..296
FT /note="Transcription factor bHLH99"
FT /id="PRO_0000358788"
FT DOMAIN 99..150
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ SEQUENCE 296 AA; 33761 MW; 1446C86F8896E11C CRC64;
MMFQQDYPHG FSLVETSLSY EMLDYFQNIV VSNSEDVASQ QNSISSSSYS SATLSCSITE
QKSHLTEKLS PLRERYGCGD FLSRKRRRRS EKTIVDKENQ RMNHIAVERN RRKQMNHFLS
ILKSMMPLSY SQPNDQASII EGTISYLKKL EQRLQSLEAQ LKATKLNQSP NIFSDFFMFP
QYSTATATAT ATASSSSSSH HHHKRLEVVA DVEVTMVERH ANIKVLTKTQ PRLLFKIINE
FNSLGLSTLH LNLTTSKDMS LFTFSVKVEA DCQLTPSGNE VANTVHEVVR RVHKER
