SIGL1_HUMAN
ID SIGL1_HUMAN Reviewed; 197 AA.
AC Q8N7X8;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=SIGLEC family-like protein 1;
GN Name=SIGLECL1; Synonyms=C19orf75;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N7X8; P05090: APOD; NbExp=3; IntAct=EBI-18052611, EBI-715495;
CC Q8N7X8; P54852: EMP3; NbExp=3; IntAct=EBI-18052611, EBI-3907816;
CC Q8N7X8; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-18052611, EBI-10243654;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK097554; BAC05098.1; -; mRNA.
DR EMBL; CH471135; EAW71998.1; -; Genomic_DNA.
DR EMBL; BC126357; AAI26358.1; -; mRNA.
DR EMBL; BC126359; AAI26360.1; -; mRNA.
DR CCDS; CCDS12827.1; -.
DR RefSeq; NP_775906.1; NM_173635.2.
DR RefSeq; XP_005258856.1; XM_005258799.4.
DR RefSeq; XP_011525123.1; XM_011526821.2.
DR AlphaFoldDB; Q8N7X8; -.
DR BioGRID; 129848; 115.
DR IntAct; Q8N7X8; 98.
DR GlyGen; Q8N7X8; 1 site.
DR BioMuta; SIGLECL1; -.
DR DMDM; 74729309; -.
DR MassIVE; Q8N7X8; -.
DR PaxDb; Q8N7X8; -.
DR PeptideAtlas; Q8N7X8; -.
DR PRIDE; Q8N7X8; -.
DR Antibodypedia; 62941; 36 antibodies from 10 providers.
DR DNASU; 284369; -.
DR Ensembl; ENST00000316401.11; ENSP00000321249.6; ENSG00000179213.14.
DR Ensembl; ENST00000601727.6; ENSP00000469601.2; ENSG00000179213.14.
DR Ensembl; ENST00000614422.4; ENSP00000480286.1; ENSG00000179213.14.
DR GeneID; 284369; -.
DR KEGG; hsa:284369; -.
DR MANE-Select; ENST00000601727.6; ENSP00000469601.2; NM_001385465.1; NP_001372394.1.
DR UCSC; uc002pwb.2; human.
DR CTD; 284369; -.
DR GeneCards; SIGLECL1; -.
DR HGNC; HGNC:26856; SIGLECL1.
DR HPA; ENSG00000179213; Tissue enriched (testis).
DR neXtProt; NX_Q8N7X8; -.
DR OpenTargets; ENSG00000179213; -.
DR PharmGKB; PA165393060; -.
DR VEuPathDB; HostDB:ENSG00000179213; -.
DR eggNOG; ENOG502RWXE; Eukaryota.
DR GeneTree; ENSGT01040000240433; -.
DR HOGENOM; CLU_096844_0_0_1; -.
DR InParanoid; Q8N7X8; -.
DR OMA; ILGPWAN; -.
DR OrthoDB; 1491667at2759; -.
DR PhylomeDB; Q8N7X8; -.
DR TreeFam; TF340027; -.
DR PathwayCommons; Q8N7X8; -.
DR SignaLink; Q8N7X8; -.
DR BioGRID-ORCS; 284369; 9 hits in 1060 CRISPR screens.
DR GenomeRNAi; 284369; -.
DR Pharos; Q8N7X8; Tdark.
DR PRO; PR:Q8N7X8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N7X8; protein.
DR Bgee; ENSG00000179213; Expressed in sperm and 41 other tissues.
DR ExpressionAtlas; Q8N7X8; baseline and differential.
DR Genevisible; Q8N7X8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0033691; F:sialic acid binding; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR SUPFAM; SSF48726; SSF48726; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..197
FT /note="SIGLEC family-like protein 1"
FT /id="PRO_0000332128"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 160..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 197 AA; 21283 MW; 4E6807E266357A25 CRC64;
MLPLLQLVPA KLLNSSCSLE KTLQCSCSFH GIPTPSVQWW MGGVPVGVDG MDGSLQVTST
MLGPWANSTI SLTEEPEMGM RLLCEGKNQN GTHALSILLM SRKSSLAAQA FVKGLIQGAI
YAGIVIALLF LCLLPLIVKH IRKKQAKKAA AIRAKKSSKV RASQELEMSL KPEEPGKPVV
ATFSESRILE KQDKRAS
