ID   SIGNS_REOVJ             Reviewed;         366 AA.
AC   P12002;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Protein sigma-NS;
DE            Short=SigmaNS;
GN   Name=S3;
OS   Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Spinareovirinae; Orthoreovirus.
OX   NCBI_TaxID=10885;
OH   NCBI_TaxID=40674; Mammalia.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3686825; DOI=10.1016/0042-6822(87)90125-5;
RA   Wiener J.R., Joklik W.K.;
RT   "Comparison of the reovirus serotype 1, 2, and 3 S3 genome segments
RT   encoding the nonstructural protein sigma NS.";
RL   Virology 161:332-339(1987).
CC   -!- FUNCTION: Protein that binds to ssRNA and may be involved in genome
CC       packaging. {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer. Interacts with protein mu-NS; in viral
CC       inclusions. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the orthoreovirus sigma-NS protein family.
CC       {ECO:0000305}.
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DR   EMBL; M18390; AAA47282.1; -; Genomic_RNA.
DR   PIR; B27401; MNXRT2.
DR   Proteomes; UP000006370; Genome.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:InterPro.
DR   GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro.
DR   InterPro; IPR002507; Reovirus_polyG_pol.
DR   Pfam; PF01518; PolyG_pol; 1.
PE   3: Inferred from homology;
KW   RNA-binding.
FT   CHAIN           1..366
FT                   /note="Protein sigma-NS"
FT                   /id="PRO_0000222760"
FT   REGION          1..11
FT                   /note="Important for ssRNA-binding and formation of
FT                   complexes"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   366 AA;  41334 MW;  EF9202C3A6FC5085 CRC64;
     MASSLRAAIS KIKRDDVGQQ VCPNYVMLRS SVNTKVVRNV VDYQIKTGGF FSCIAMLRPL
     QYAKRERLLG QRNLERIAAR DVLQTRDLHS LCMPTPDAPM TNYQASTMRE LVCDHFKVDH
     VDGLRYVPMD DRYSPSSLAR LFTMGMAGLH ITTEPAYKRV PIMHLAADLD CMTFALPYMI
     TVDGDTVVPV APTLPAERLL DDGFKGYGCL DISYGCEVDA NNRSAGDQSM DSSRCINELY
     TAETAEAICI LKTCLILNCM QFKLEMDDLA HNGFELDKVQ MMIPFSERVF RMASAFATID
     VQCFRFCLLM KDKNLKIDMR ETMRLWTRAG SDDAISTSSL TISLDRGRWV AMDMNEVRLL
     VFPARV