ID   SIGS_STAA2              Reviewed;         156 AA.
AC   A6U2P0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=RNA polymerase sigma factor SigS;
GN   Name=sigS; OrderedLocusNames=SaurJH1_1864;
OS   Staphylococcus aureus (strain JH1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=359787;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JH1;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Ivanova N., Tomasz A., Richardson P.;
RT   "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus
RT   JH1.";
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. Sigma-S contributes to the protection against external
CC       stress, thus playing a role in cellular fitness and survival (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABR52708.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000736; ABR52708.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000671057.1; NC_009632.1.
DR   AlphaFoldDB; A6U2P0; -.
DR   SMR; A6U2P0; -.
DR   KEGG; sah:SaurJH1_1864; -.
DR   HOGENOM; CLU_047691_20_2_9; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Sigma factor; Transcription; Transcription regulation.
FT   CHAIN           1..156
FT                   /note="RNA polymerase sigma factor SigS"
FT                   /id="PRO_0000367446"
FT   DNA_BIND        126..145
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOTIF           29..44
FT                   /note="Polymerase core binding"
SQ   SEQUENCE   156 AA;  19161 MW;  63CDABF0A4C02B0E CRC64;
     MKFNDVYNKH HKIIHHLLKK YNISYNYDEY YQLLLIKMWQ LSQIYKPSSK QSLSSFLFTR
     LNYYLIDLFR QQNQLKDVIL CENNSPTLTE QPTYFNEHDL RLQDIFKLLN HRERLWLKLY
     LEGYKQFEIA EIMSLSLSTI KLIKMSVKRK CQHNFN