ID   SIGS_STAAB              Reviewed;         156 AA.
AC   Q2YTL0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=RNA polymerase sigma factor SigS;
GN   Name=sigS; OrderedLocusNames=SAB1635;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. Sigma-S contributes to the protection against external
CC       stress, thus playing a role in cellular fitness and survival (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAI81324.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ938182; CAI81324.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000671046.1; NC_007622.1.
DR   AlphaFoldDB; Q2YTL0; -.
DR   SMR; Q2YTL0; -.
DR   KEGG; sab:SAB1635; -.
DR   HOGENOM; CLU_047691_20_2_9; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Sigma factor; Transcription; Transcription regulation.
FT   CHAIN           1..156
FT                   /note="RNA polymerase sigma factor SigS"
FT                   /id="PRO_0000367444"
FT   DNA_BIND        126..145
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOTIF           29..44
FT                   /note="Polymerase core binding"
SQ   SEQUENCE   156 AA;  19163 MW;  F13D45FF69DEC410 CRC64;
     MKFNDVYNKH HKIIHHLLKK YNISYNYDEY YQLLLIKMWQ LSQIYKPSSK QSLSSFLFTR
     LNFYLIDLFR QQNQLKDVIL CENNSPTLTE QPTYFNEHDL RLQDIFKFLN HRERLWLKLY
     LEGYKQFEIA EIMSLSLSTI KLIKTSVKRK CQHNFK