ID   SIGS_STAAM              Reviewed;         156 AA.
AC   Q99T92;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=RNA polymerase sigma factor SigS;
GN   Name=sigS; OrderedLocusNames=SAV1777;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. Sigma-S contributes to the protection against external
CC       stress, thus playing a role in cellular fitness and survival (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
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DR   EMBL; BA000017; BAB57939.1; -; Genomic_DNA.
DR   RefSeq; WP_000671057.1; NC_002758.2.
DR   AlphaFoldDB; Q99T92; -.
DR   SMR; Q99T92; -.
DR   PaxDb; Q99T92; -.
DR   EnsemblBacteria; BAB57939; BAB57939; SAV1777.
DR   KEGG; sav:SAV1777; -.
DR   HOGENOM; CLU_047691_20_2_9; -.
DR   OMA; IILCENH; -.
DR   BioCyc; SAUR158878:SAV_RS09540-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Sigma factor; Transcription; Transcription regulation.
FT   CHAIN           1..156
FT                   /note="RNA polymerase sigma factor SigS"
FT                   /id="PRO_0000367451"
FT   DNA_BIND        126..145
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOTIF           29..44
FT                   /note="Polymerase core binding"
SQ   SEQUENCE   156 AA;  19161 MW;  63CDABF0A4C02B0E CRC64;
     MKFNDVYNKH HKIIHHLLKK YNISYNYDEY YQLLLIKMWQ LSQIYKPSSK QSLSSFLFTR
     LNYYLIDLFR QQNQLKDVIL CENNSPTLTE QPTYFNEHDL RLQDIFKLLN HRERLWLKLY
     LEGYKQFEIA EIMSLSLSTI KLIKMSVKRK CQHNFN