ID   SIGS_STAAT              Reviewed;         156 AA.
AC   A8Z4K2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=RNA polymerase sigma factor SigS;
GN   Name=sigS; OrderedLocusNames=USA300HOU_1766;
OS   Staphylococcus aureus (strain USA300 / TCH1516).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=451516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300 / TCH1516;
RX   PubMed=17986343; DOI=10.1186/1471-2180-7-99;
RA   Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S.,
RA   Mason E.O. Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y., Igboeli O.,
RA   Petrosino J., Tirumalai M., Uzman A., Fox G.E., Cardenas A.M., Muzny D.M.,
RA   Hemphill L., Ding Y., Dugan S., Blyth P.R., Buhay C.J., Dinh H.H.,
RA   Hawes A.C., Holder M., Kovar C.L., Lee S.L., Liu W., Nazareth L.V.,
RA   Wang Q., Zhou J., Kaplan S.L., Weinstock G.M.;
RT   "Subtle genetic changes enhance virulence of methicillin resistant and
RT   sensitive Staphylococcus aureus.";
RL   BMC Microbiol. 7:99-99(2007).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. Sigma-S contributes to the protection against external
CC       stress, thus playing a role in cellular fitness and survival (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABX29772.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000730; ABX29772.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000671052.1; NC_010079.1.
DR   AlphaFoldDB; A8Z4K2; -.
DR   SMR; A8Z4K2; -.
DR   KEGG; sax:USA300HOU_1766; -.
DR   HOGENOM; CLU_047691_20_2_9; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Sigma factor; Transcription; Transcription regulation.
FT   CHAIN           1..156
FT                   /note="RNA polymerase sigma factor SigS"
FT                   /id="PRO_0000367456"
FT   DNA_BIND        126..145
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOTIF           29..44
FT                   /note="Polymerase core binding"
SQ   SEQUENCE   156 AA;  19136 MW;  7306285B34C00B2C CRC64;
     MKFNDVYNKH HKIIHHLLKK YNISYNYDEY YQLLLIKMWQ LSQIYKPSSK QSLSSFLFTR
     LNFYLIDLFR QQNQLKDVIL CENNSPTLTE QPTYFNEHDL RLQDIFKLLN QRERLWLKLY
     LEGYKQFEIA EIMSLSLSTI KLIKMSVKRK CQHNFN