ID   SIGV_BACSU              Reviewed;         166 AA.
AC   O05404;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 134.
DE   RecName: Full=RNA polymerase sigma factor SigV;
GN   Name=sigV; OrderedLocusNames=BSU27120;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9308178; DOI=10.1099/00221287-143-9-2939;
RA   Sorokin A., Bolotin A., Purnelle B., Hilbert H., Lauber J.,
RA   Duesterhoeft A., Ehrlich S.D.;
RT   "Sequence of the Bacillus subtilis genome region in the vicinity of the lev
RT   operon reveals two new extracytoplasmic function RNA polymerase sigma
RT   factors SigV and SigZ.";
RL   Microbiology 143:2939-2943(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [3]
RP   INTERACTION WITH RSIV.
RC   STRAIN=168;
RX   PubMed=14993308; DOI=10.1099/mic.0.26712-0;
RA   Yoshimura M., Asai K., Sadaie Y., Yoshikawa H.;
RT   "Interaction of Bacillus subtilis extracytoplasmic function (ECF) sigma
RT   factors with the N-terminal regions of their potential anti-sigma
RT   factors.";
RL   Microbiology 150:591-599(2004).
RN   [4]
RP   FUNCTION.
RC   STRAIN=168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB
RC   3610 / NRRL NRS-744 / VKM B-501;
RX   PubMed=16274938; DOI=10.1016/j.femsle.2005.09.056;
RA   Zellmeier S., Hofmann C., Thomas S., Wiegert T., Schumann W.;
RT   "Identification of sigmaV-dependent genes of Bacillus subtilis.";
RL   FEMS Microbiol. Lett. 253:221-229(2005).
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. Positively regulates the expression of proteins involved in
CC       stress responses against bacitracin, paraquat and tellurite.
CC       {ECO:0000269|PubMed:16274938}.
CC   -!- SUBUNIT: Interacts with RsiV. {ECO:0000269|PubMed:14993308}.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. ECF subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U93874; AAB80871.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB14654.1; -; Genomic_DNA.
DR   PIR; G69706; G69706.
DR   RefSeq; NP_390590.1; NC_000964.3.
DR   RefSeq; WP_004398891.1; NZ_JNCM01000036.1.
DR   AlphaFoldDB; O05404; -.
DR   SMR; O05404; -.
DR   IntAct; O05404; 2.
DR   STRING; 224308.BSU27120; -.
DR   PaxDb; O05404; -.
DR   PRIDE; O05404; -.
DR   DNASU; 937591; -.
DR   EnsemblBacteria; CAB14654; CAB14654; BSU_27120.
DR   GeneID; 937591; -.
DR   KEGG; bsu:BSU27120; -.
DR   PATRIC; fig|224308.179.peg.2945; -.
DR   eggNOG; COG1595; Bacteria.
DR   InParanoid; O05404; -.
DR   OMA; IKSWFYK; -.
DR   PhylomeDB; O05404; -.
DR   BioCyc; BSUB:BSU27120-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016987; F:sigma factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006352; P:DNA-templated transcription, initiation; IEA:InterPro.
DR   GO; GO:0006950; P:response to stress; IEA:UniProt.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR039425; RNA_pol_sigma-70-like.
DR   InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR   InterPro; IPR000838; RNA_pol_sigma70_ECF_CS.
DR   InterPro; IPR007627; RNA_pol_sigma70_r2.
DR   InterPro; IPR013249; RNA_pol_sigma70_r4_t2.
DR   InterPro; IPR013325; RNA_pol_sigma_r2.
DR   InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR43133; PTHR43133; 1.
DR   Pfam; PF04542; Sigma70_r2; 1.
DR   Pfam; PF08281; Sigma70_r4_2; 1.
DR   SUPFAM; SSF88659; SSF88659; 1.
DR   SUPFAM; SSF88946; SSF88946; 1.
DR   TIGRFAMs; TIGR02937; sigma70-ECF; 1.
DR   PROSITE; PS01063; SIGMA70_ECF; 1.
PE   1: Evidence at protein level;
KW   Activator; DNA-binding; Reference proteome; Sigma factor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..166
FT                   /note="RNA polymerase sigma factor SigV"
FT                   /id="PRO_0000094015"
FT   DNA_BIND        131..150
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   MOTIF           38..51
FT                   /note="Polymerase core binding"
SQ   SEQUENCE   166 AA;  19713 MW;  C85FE7FCB03A44AF CRC64;
     MKKKQTTKAL LVTCITDHKQ DFYRLAFSYV KNQDDALDIV QESIKKALSS VETVRNPETI
     KSWFYKILVR TAIDFLRKQK KIRVMDDETI EFLSKGKEDH YKDTDLHEAL DELPYRYKTI
     IILRFFEDLK LEEIAEITGE NTNTVKTRLY RALKLMRIQL TKEDLS