ID   SIKE1_BOVIN             Reviewed;         207 AA.
AC   Q0VCF3;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Suppressor of IKBKE 1;
DE   AltName: Full=Suppressor of IKK-epsilon;
GN   Name=SIKE1; Synonyms=SIKE;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal brain;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that plays
CC       an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-
CC       mediated activation of interferon-stimulated response elements (ISRE)
CC       and the IFN-beta promoter. May act by disrupting the interactions of
CC       IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit
CC       NF-kappa-B activation pathways (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IKBKE and TBK1 via its coiled coil region.
CC       Interaction with TBK1 is disrupted upon viral infection or TLR3
CC       stimulation. Interacts with CDC42BPB. {ECO:0000250|UniProtKB:Q9BRV8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIKE family. {ECO:0000305}.
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DR   EMBL; BC120197; AAI20198.1; -; mRNA.
DR   RefSeq; NP_001068749.1; NM_001075281.2.
DR   AlphaFoldDB; Q0VCF3; -.
DR   SMR; Q0VCF3; -.
DR   STRING; 9913.ENSBTAP00000021254; -.
DR   PaxDb; Q0VCF3; -.
DR   PRIDE; Q0VCF3; -.
DR   Ensembl; ENSBTAT00000021254; ENSBTAP00000021254; ENSBTAG00000015977.
DR   GeneID; 506848; -.
DR   KEGG; bta:506848; -.
DR   CTD; 80143; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015977; -.
DR   VGNC; VGNC:34621; SIKE1.
DR   eggNOG; ENOG502QTKS; Eukaryota.
DR   GeneTree; ENSGT00390000018003; -.
DR   HOGENOM; CLU_073167_1_0_1; -.
DR   InParanoid; Q0VCF3; -.
DR   OMA; KVLCDAR; -.
DR   OrthoDB; 1368908at2759; -.
DR   TreeFam; TF324337; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000015977; Expressed in neutrophil and 110 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   InterPro; IPR008555; SIKE.
DR   PANTHER; PTHR12186; PTHR12186; 1.
DR   Pfam; PF05769; SIKE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..207
FT                   /note="Suppressor of IKBKE 1"
FT                   /id="PRO_0000299049"
FT   COILED          70..102
FT                   /evidence="ECO:0000255"
FT   COILED          162..192
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   207 AA;  23675 MW;  5DCAC6BB41F09E68 CRC64;
     MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL PDQYQEDASD
     IKDMSKYKPH ILLSQENTQI RDLQQENREL WVSLEEHQDA LELIMSKYRK QMLQLMVAKK
     AADAEPVLKA HQSHSAEIEN QIDRICEMGE VMRKAVQMDD DQFCKIQEKL AQLELENKEL
     RELLSISSES LQVRKESSVD TASQGIK