ID   SIKE1_PONAB             Reviewed;         207 AA.
AC   Q5R8J5;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Suppressor of IKBKE 1;
DE   AltName: Full=Suppressor of IKK-epsilon;
GN   Name=SIKE1; Synonyms=SIKE;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that plays
CC       an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-
CC       mediated activation of interferon-stimulated response elements (ISRE)
CC       and the IFN-beta promoter. May act by disrupting the interactions of
CC       IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit
CC       NF-kappa-B activation pathways (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IKBKE and TBK1 via its coiled coil region.
CC       Interaction with TBK1 is disrupted upon viral infection or TLR3
CC       stimulation. Interacts with CDC42BPB. {ECO:0000250|UniProtKB:Q9BRV8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIKE family. {ECO:0000305}.
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DR   EMBL; CR859757; CAH91915.1; -; mRNA.
DR   RefSeq; NP_001126110.1; NM_001132638.1.
DR   AlphaFoldDB; Q5R8J5; -.
DR   SMR; Q5R8J5; -.
DR   STRING; 9601.ENSPPYP00000001160; -.
DR   GeneID; 100173065; -.
DR   KEGG; pon:100173065; -.
DR   CTD; 80143; -.
DR   eggNOG; ENOG502QTKS; Eukaryota.
DR   HOGENOM; CLU_073167_1_0_1; -.
DR   InParanoid; Q5R8J5; -.
DR   OrthoDB; 1368908at2759; -.
DR   TreeFam; TF324337; -.
DR   Proteomes; UP000001595; Chromosome 1.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008555; SIKE.
DR   PANTHER; PTHR12186; PTHR12186; 1.
DR   Pfam; PF05769; SIKE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..207
FT                   /note="Suppressor of IKBKE 1"
FT                   /id="PRO_0000299053"
FT   COILED          70..102
FT                   /evidence="ECO:0000255"
FT   COILED          162..193
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   207 AA;  23753 MW;  4C4588613F132988 CRC64;
     MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGTAL PDQYQEDASD
     MKDMSKYKPH ILLSQENTQI RDLQQENREL WISLEEHQDA LELIMSKYRK QMLQLMVAKK
     AVDAEPVLKA HQSHSAEIES QIDRICEMGE VMRKAVQMDD DQFCKIQEKL AQLELENKEL
     RELLSISSES LQARKENSMD TASQAIK