ID   SIKE1_RAT               Reviewed;         207 AA.
AC   Q5FWT9;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Suppressor of IKBKE 1;
DE   AltName: Full=Suppressor of IKK-epsilon;
GN   Name=Sike1; Synonyms=Sike;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that plays
CC       an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-
CC       mediated activation of interferon-stimulated response elements (ISRE)
CC       and the IFN-beta promoter. May act by disrupting the interactions of
CC       IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit
CC       NF-kappa-B activation pathways (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IKBKE and TBK1 via its coiled coil region.
CC       Interaction with TBK1 is disrupted upon viral infection or TLR3
CC       stimulation. Interacts with CDC42BPB. {ECO:0000250|UniProtKB:Q9BRV8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIKE family. {ECO:0000305}.
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DR   EMBL; BC089208; AAH89208.1; -; mRNA.
DR   RefSeq; NP_001012182.1; NM_001012182.2.
DR   AlphaFoldDB; Q5FWT9; -.
DR   SMR; Q5FWT9; -.
DR   STRING; 10116.ENSRNOP00000024270; -.
DR   PhosphoSitePlus; Q5FWT9; -.
DR   PaxDb; Q5FWT9; -.
DR   PRIDE; Q5FWT9; -.
DR   Ensembl; ENSRNOT00000024270; ENSRNOP00000024270; ENSRNOG00000017502.
DR   GeneID; 362007; -.
DR   KEGG; rno:362007; -.
DR   CTD; 80143; -.
DR   RGD; 1311316; Sike1.
DR   eggNOG; ENOG502QTKS; Eukaryota.
DR   GeneTree; ENSGT00390000018003; -.
DR   HOGENOM; CLU_073167_1_0_1; -.
DR   InParanoid; Q5FWT9; -.
DR   OMA; KVLCDAR; -.
DR   OrthoDB; 1368908at2759; -.
DR   PhylomeDB; Q5FWT9; -.
DR   TreeFam; TF324337; -.
DR   PRO; PR:Q5FWT9; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000017502; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q5FWT9; RN.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019901; F:protein kinase binding; ISO:RGD.
DR   GO; GO:0031267; F:small GTPase binding; ISO:RGD.
DR   InterPro; IPR008555; SIKE.
DR   PANTHER; PTHR12186; PTHR12186; 1.
DR   Pfam; PF05769; SIKE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..207
FT                   /note="Suppressor of IKBKE 1"
FT                   /id="PRO_0000299054"
FT   COILED          70..102
FT                   /evidence="ECO:0000255"
FT   COILED          162..192
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   207 AA;  23578 MW;  0ECD69EBFB485265 CRC64;
     MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGAVL PEQYQEDASD
     VKDMSKYKPH ILLSQENTQI RDLQQENREL WVSLEEHQDA LELIMSKYRK QMLQLMVAKQ
     AVDAEPVLKA HQSHSAEIES QIDRICEMGA VMRRAVQVDD NQFCKIQEKL AQLELENKEL
     RELLSISSES LQVGKESSVA PEAQTIR