ID   SIKE1_XENTR             Reviewed;         207 AA.
AC   Q5I033;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Suppressor of IKBKE 1;
DE   AltName: Full=Suppressor of IKK-epsilon;
GN   Name=sike1; Synonyms=sike; ORFNames=TTpA011e05.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Suppressor of IKK-epsilon. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIKE family. {ECO:0000305}.
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DR   EMBL; CR848255; CAJ83158.1; -; mRNA.
DR   EMBL; BC088764; AAH88764.1; -; mRNA.
DR   RefSeq; NP_001011474.1; NM_001011474.1.
DR   RefSeq; XP_012816905.1; XM_012961451.1.
DR   AlphaFoldDB; Q5I033; -.
DR   SMR; Q5I033; -.
DR   PaxDb; Q5I033; -.
DR   DNASU; 496965; -.
DR   Ensembl; ENSXETT00000046368; ENSXETP00000046368; ENSXETG00000021446.
DR   GeneID; 496965; -.
DR   KEGG; xtr:496965; -.
DR   CTD; 80143; -.
DR   Xenbase; XB-GENE-1003385; sike1.
DR   eggNOG; ENOG502QTKS; Eukaryota.
DR   HOGENOM; CLU_073167_1_0_1; -.
DR   InParanoid; Q5I033; -.
DR   OMA; KIHEMAT; -.
DR   OrthoDB; 1368908at2759; -.
DR   TreeFam; TF324337; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000021446; Expressed in ovary and 14 other tissues.
DR   ExpressionAtlas; Q5I033; differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008555; SIKE.
DR   PANTHER; PTHR12186; PTHR12186; 1.
DR   Pfam; PF05769; SIKE; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..207
FT                   /note="Suppressor of IKBKE 1"
FT                   /id="PRO_0000299056"
FT   REGION          186..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          4..32
FT                   /evidence="ECO:0000255"
FT   COILED          154..193
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   207 AA;  23997 MW;  4B4B7AD69ED14C0D CRC64;
     MTCTIDKILQ DAKTLLERLK DHDNAAESLI DQSSALHKRV EAMKEVGTAM PEKYQEELAD
     IKDASKLKPH VLLCQENTQI RDLQQENKEL WVSLEEHQYA LELIMSKYRK QMLQLVANKK
     PAPTEPVLEA HKTFSSDLEC QIDRICVMGD IMRDAIQLDE DKAYNIQEKL AQLELENKEL
     REILSTSKES LHSSKRESEW NFSEKTQ