BH110_ARATH
ID BH110_ARATH Reviewed; 453 AA.
AC Q9SFZ3;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transcription factor bHLH110;
DE AltName: Full=Basic helix-loop-helix protein 110;
DE Short=AtbHLH110;
DE Short=bHLH 110;
DE AltName: Full=Transcription factor EN 59;
DE AltName: Full=bHLH transcription factor bHLH110;
GN Name=BHLH110; Synonyms=EN59; OrderedLocusNames=At1g27660;
GN ORFNames=T22C5.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF24944.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BX814188; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
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DR EMBL; AC012375; AAF24944.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30860.1; -; Genomic_DNA.
DR EMBL; BX814188; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; F86401; F86401.
DR RefSeq; NP_174087.1; NM_102531.4.
DR AlphaFoldDB; Q9SFZ3; -.
DR SMR; Q9SFZ3; -.
DR STRING; 3702.AT1G27660.1; -.
DR PaxDb; Q9SFZ3; -.
DR PRIDE; Q9SFZ3; -.
DR ProteomicsDB; 240342; -.
DR EnsemblPlants; AT1G27660.1; AT1G27660.1; AT1G27660.
DR GeneID; 839658; -.
DR Gramene; AT1G27660.1; AT1G27660.1; AT1G27660.
DR KEGG; ath:AT1G27660; -.
DR Araport; AT1G27660; -.
DR TAIR; locus:2199216; AT1G27660.
DR eggNOG; ENOG502QUG3; Eukaryota.
DR HOGENOM; CLU_052914_0_0_1; -.
DR InParanoid; Q9SFZ3; -.
DR OMA; FPINGDY; -.
DR OrthoDB; 1232172at2759; -.
DR PhylomeDB; Q9SFZ3; -.
DR PRO; PR:Q9SFZ3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SFZ3; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11393; bHLH_AtbHLH_like; 1.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045239; bHLH95_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..453
FT /note="Transcription factor bHLH110"
FT /id="PRO_0000358796"
FT DOMAIN 322..371
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 49557 MW; A03C48BB8FC7619D CRC64;
MDSANLHQLQ DQLQLVGSSS SSSSLDNNSD PSCYGASSAH QWSPGGISLN SVSLSHNYNN
EMLNTRAHNN NNNNNTSECM SLSSIHNHSL IQQQDFPLQW PHDQSSYQHH EGLLKIKEEL
SSSTISDHQE GISKFTDMLN SPVITNYLKI NEHKDYTEKL LLKSMSSGFP INGDYGSSLP
SSSSSSSPSS QSHRGNFSQI YPSVNISSLS ESRKMSMDDM SNISRPFDIN MQVFDGRLFE
GNVLVPPFNA QEISSLGMSR GSLPSFGLPF HHHLQQTLPH LSSSPTHQME MFSNEPQTSE
GKRHNFLMAT KAGENASKKP RVESRSSCPP FKVRKEKLGD RIAALQQLVS PFGKTDTASV
LMEAIGYIKF LQSQIETLSV PYMRASRNRP GKASQLVSQS QEGDEEETRD LRSRGLCLVP
LSCMTYVTGD GGDGGGGVGT GFWPTPPGFG GGT
