SIL1_ASHGO
ID SIL1_ASHGO Reviewed; 383 AA.
AC Q758U2;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 88.
DE RecName: Full=Nucleotide exchange factor SIL1;
DE Flags: Precursor;
GN Name=SIL1; OrderedLocusNames=AEL340W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Required for protein translocation and folding in the
CC endoplasmic reticulum (ER). Functions as a nucleotide exchange factor
CC for the ER lumenal chaperone KAR2 (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with KAR2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SIL1 family. {ECO:0000305}.
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DR EMBL; AE016818; AAS52344.1; -; Genomic_DNA.
DR RefSeq; NP_984520.1; NM_209873.1.
DR AlphaFoldDB; Q758U2; -.
DR SMR; Q758U2; -.
DR STRING; 33169.AAS52344; -.
DR EnsemblFungi; AAS52344; AAS52344; AGOS_AEL340W.
DR GeneID; 4620690; -.
DR KEGG; ago:AGOS_AEL340W; -.
DR eggNOG; KOG2160; Eukaryota.
DR HOGENOM; CLU_034955_0_0_1; -.
DR InParanoid; Q758U2; -.
DR OMA; GLDIRMN; -.
DR Proteomes; UP000000591; Chromosome V.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR GO; GO:0006616; P:SRP-dependent cotranslational protein targeting to membrane, translocation; IEA:EnsemblFungi.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR031884; Sil1_fungi.
DR Pfam; PF16782; SIL1; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Protein transport; Reference proteome; Signal;
KW Translocation; Transport.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..383
FT /note="Nucleotide exchange factor SIL1"
FT /id="PRO_0000223359"
FT MOTIF 380..383
FT /note="Prevents secretion from ER"
FT /evidence="ECO:0000255"
SQ SEQUENCE 383 AA; 43998 MW; BDC81E26AEB71D67 CRC64;
MYWKKLLFAI ASAAALAAVD PETEGSELQT ICSGGECYPR LFKALQDWST IKEGQQIPPG
LDIRVDLSTG KKQARLPIPN EASNMENGIQ VVDDSSDYEF TKEFQLVRAQ VASGAPDYNV
VIKQLDDLVE YASDYTLGYK IITHEFTLLQ ELIFGQDVPI SVKELSSRII VACLRNNTPC
LDFVNTRFPD FVRHLLQEAV DYGRQATDAV EARTQIKRYL SIVEPLLINE PQPINEEALK
QLYEVNDQTV QLKVLLIMAR LYKGRSHNDD ISKRSLESTD VQRWTTELSK AIQSKHLDDF
HVRELFHGLY ALKKEHGRAV KTYPTFLGWL AEETEARKQR MTQDKQPRDL EQMEFDRLLI
ESRHMVFGNP MAHRIKNMEY DEL