ID   SIL1_CANGA              Reviewed;         339 AA.
AC   Q6FUS3;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Nucleotide exchange factor SIL1;
DE   Flags: Precursor;
GN   Name=SIL1; OrderedLocusNames=CAGL0F01089g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for protein translocation and folding in the
CC       endoplasmic reticulum (ER). Functions as a nucleotide exchange factor
CC       for the ER lumenal chaperone KAR2 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with KAR2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SIL1 family. {ECO:0000305}.
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DR   EMBL; CR380952; CAG58945.1; -; Genomic_DNA.
DR   RefSeq; XP_446021.1; XM_446021.1.
DR   AlphaFoldDB; Q6FUS3; -.
DR   SMR; Q6FUS3; -.
DR   STRING; 5478.XP_446021.1; -.
DR   EnsemblFungi; CAG58945; CAG58945; CAGL0F01089g.
DR   GeneID; 2887649; -.
DR   KEGG; cgr:CAGL0F01089g; -.
DR   CGD; CAL0129362; CAGL0F01089g.
DR   VEuPathDB; FungiDB:CAGL0F01089g; -.
DR   eggNOG; KOG2160; Eukaryota.
DR   HOGENOM; CLU_818876_0_0_1; -.
DR   InParanoid; Q6FUS3; -.
DR   OMA; EHLEDSH; -.
DR   Proteomes; UP000002428; Chromosome F.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR031884; Sil1_fungi.
DR   Pfam; PF16782; SIL1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Protein transport; Reference proteome; Signal;
KW   Translocation; Transport.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..339
FT                   /note="Nucleotide exchange factor SIL1"
FT                   /id="PRO_0000223361"
FT   MOTIF           336..339
FT                   /note="Prevents secretion from ER"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   339 AA;  38225 MW;  45FB1C2135123780 CRC64;
     MVAKVWSRVI LIFIATVMVF ASSQQGDANK VNTASPPGAN GIAYASVVAG GSNHVSAAGS
     VTGDGVQLPN AEVDIDWLEE HLEDSHDYEK GYDLVEQHFN KLLVGNNADA SFKVRELASR
     LILGTLRNNP PVKRLIWDQH PLFVSQVFDL YIGNALKQGS GNPLKYPLLK RYLSILLELI
     PFNRDFRFEE DYKDILDKLY TESDVPSDIK IKVLELITLD YSNIKGASGW IDRITNVLTD
     SEMGLDELHK RTFFNAMHAL KSEDPKLKLP TNFLNWLAQE TKERAHNLKL AQAQADDNDL
     KVRDLEQEEF DQRLVDSRHS VFGNPMAARM KDPYIVDEL