ID   SIL1_DEBHA              Reviewed;         427 AA.
AC   Q6BTV5; B5RTC4;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Nucleotide exchange factor SIL1;
DE   Flags: Precursor;
GN   Name=SIL1; OrderedLocusNames=DEHA2C15664g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for protein translocation and folding in the
CC       endoplasmic reticulum (ER). Functions as a nucleotide exchange factor
CC       for the ER lumenal chaperone KAR2 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with KAR2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-
CC       ProRule:PRU10138}.
CC   -!- SIMILARITY: Belongs to the SIL1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382135; CAR65586.1; -; Genomic_DNA.
DR   RefSeq; XP_002770223.1; XM_002770177.1.
DR   AlphaFoldDB; Q6BTV5; -.
DR   SMR; Q6BTV5; -.
DR   STRING; 4959.XP_002770223.1; -.
DR   EnsemblFungi; CAR65586; CAR65586; DEHA2C15664g.
DR   GeneID; 8998396; -.
DR   KEGG; dha:DEHA2C15664g; -.
DR   VEuPathDB; FungiDB:DEHA2C15664g; -.
DR   eggNOG; KOG2160; Eukaryota.
DR   HOGENOM; CLU_034955_0_0_1; -.
DR   InParanoid; Q6BTV5; -.
DR   OMA; GLDIRMN; -.
DR   OrthoDB; 1501690at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR031884; Sil1_fungi.
DR   Pfam; PF16782; SIL1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS00014; ER_TARGET; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Protein transport; Reference proteome; Signal;
KW   Translocation; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..427
FT                   /note="Nucleotide exchange factor SIL1"
FT                   /id="PRO_0000223362"
FT   MOTIF           424..427
FT                   /note="Prevents secretion from ER"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10138"
SQ   SEQUENCE   427 AA;  47943 MW;  ACCDA7231D0A3B3B CRC64;
     MKLSKGVLSS ILLTLLIKPI ESSIVNTDGE LICAPNNPTD CYPKIFEPTT EWQTIREGQD
     IPAGLHVRLN MENLAREAKI LDPSEETEGS SELMVNAEQN NDNGDNSHQM TNEDQANEIQ
     QKIKEFKQTQ GKSKVSTVDL NDFQSSVDEV QHYREGGDAN RLSTALDTLI DLSHDIEFGV
     KLTQDSSVFR SLVDVSKSVQ DEDLQEKVYR IMGSSLRNNP DAVNHVLKNQ DATFVECLFD
     KLDTDASDVI KKRILGIIHA LTQNSHFNAK YFNSNNANSA VDSLISVFPS LESQSQTRLM
     NILEDLKLLG GANSNEKRAI EESADPKSQY SHFLQHSLAD SGVASEDQFK LYFNKLSEVH
     SQDKSLKPSK AFMEWLSKEA ELRSKGNKER DSSYTEEDRQ FDQDLLRARH VVFGNPMGLR
     KALADEL