BH111_ARATH
ID BH111_ARATH Reviewed; 319 AA.
AC Q9FYJ6; C0SUY5; F4I7V0; Q6NNL5;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Transcription factor bHLH111;
DE AltName: Full=Basic helix-loop-helix protein 111;
DE Short=AtbHLH111;
DE Short=bHLH 111;
DE AltName: Full=Transcription factor EN 66;
DE AltName: Full=bHLH transcription factor bHLH111;
GN Name=BHLH111; Synonyms=EN66; OrderedLocusNames=At1g31050; ORFNames=F17F8.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12679534; DOI=10.1093/molbev/msg088;
RA Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT "The basic helix-loop-helix transcription factor family in plants: a
RT genome-wide study of protein structure and functional diversity.";
RL Mol. Biol. Evol. 20:735-747(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=12897250; DOI=10.1105/tpc.013839;
RA Toledo-Ortiz G., Huq E., Quail P.H.;
RT "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL Plant Cell 15:1749-1770(2003).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=14600211; DOI=10.1105/tpc.151140;
RA Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E., Heim M.A.,
RA Jakoby M., Werber M., Weisshaar B.;
RT "Update on the basic helix-loop-helix transcription factor gene family in
RT Arabidopsis thaliana.";
RL Plant Cell 15:2497-2502(2003).
CC -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9FYJ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9FYJ6-2; Sequence=VSP_036099, VSP_036100;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEE31309.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At1g31050 and At1g31060.; Evidence={ECO:0000305};
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DR EMBL; AC000107; AAF98179.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31309.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BT010791; AAR24158.1; -; mRNA.
DR EMBL; BT011271; AAR92307.1; -; mRNA.
DR EMBL; AB493488; BAH30326.1; -; mRNA.
DR PIR; A86436; A86436.
DR AlphaFoldDB; Q9FYJ6; -.
DR SMR; Q9FYJ6; -.
DR IntAct; Q9FYJ6; 7.
DR STRING; 3702.AT1G31050.1; -.
DR PaxDb; Q9FYJ6; -.
DR PeptideAtlas; Q9FYJ6; -.
DR EnsemblPlants; AT1G31050.1; AT1G31050.1; AT1G31050.
DR Gramene; AT1G31050.1; AT1G31050.1; AT1G31050.
DR Araport; AT1G31050; -.
DR eggNOG; ENOG502QPTJ; Eukaryota.
DR HOGENOM; CLU_043465_1_0_1; -.
DR InParanoid; Q9FYJ6; -.
DR PhylomeDB; Q9FYJ6; -.
DR PRO; PR:Q9FYJ6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FYJ6; baseline and differential.
DR Genevisible; Q9FYJ6; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd11393; bHLH_AtbHLH_like; 1.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045239; bHLH95_bHLH.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..319
FT /note="Transcription factor bHLH111"
FT /id="PRO_0000358797"
FT DOMAIN 195..244
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..247
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_036099"
FT VAR_SEQ 248..249
FT /note="VK -> MQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.3"
FT /id="VSP_036100"
SQ SEQUENCE 319 AA; 36231 MW; 61695AD23A00EAA9 CRC64;
MDHHHHIASR NSSTTSELPS FEPACHNGNG NGWIYDPNQV RYDQSSDQRL SKLTDLVGKH
WSIAPPNNPD MNHNLHHHFD HDHSQNDDIS MYRQALEVKN EEDLCYNNGS SGGGSLFHDP
IESSRSFLDI RLSRPLTDIN PSFKPCFKAL NVSEFNKKEH QTASLAAVRL GTTNAGKKKR
CEEISDEVSK KAKCSEGSTL SPEKELPKAK LRDKITTLQQ IVSPFGKTDT ASVLQEAITY
INFYQEQVKL LSTPYMKNSS MKDPWGGWDR EDHNKRGPKH LDLRSRGLCL VPISYTPIAY
RDNSATDYWN PTYRGSLYR
