ID   SIL1_XENLA              Reviewed;         456 AA.
AC   Q6NUA7;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Nucleotide exchange factor SIL1;
DE   Flags: Precursor;
GN   Name=sil1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for protein translocation and folding in the
CC       endoplasmic reticulum (ER). Functions as a nucleotide exchange factor
CC       for the ER lumenal chaperone HSPA5. {ECO:0000250|UniProtKB:Q9H173}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC       {ECO:0000250|UniProtKB:Q9H173}.
CC   -!- SIMILARITY: Belongs to the SIL1 family. {ECO:0000305}.
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DR   EMBL; BC068689; AAH68689.1; -; mRNA.
DR   RefSeq; NP_001084696.1; NM_001091227.1.
DR   AlphaFoldDB; Q6NUA7; -.
DR   SMR; Q6NUA7; -.
DR   DNASU; 414657; -.
DR   GeneID; 414657; -.
DR   KEGG; xla:414657; -.
DR   CTD; 414657; -.
DR   Xenbase; XB-GENE-5898543; sil1.L.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 414657; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Protein transport; Reference proteome;
KW   Signal; Translocation; Transport.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..456
FT                   /note="Nucleotide exchange factor SIL1"
FT                   /id="PRO_0000223357"
FT   REGION          102..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        191
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        233
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        347
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        386
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   456 AA;  52322 MW;  70057DBECECB04F5 CRC64;
     MDLYCSFIRI SNHVKMSTFI LLTLCFYVAL SDRSPEYALT KVTEAEDDGN VEAIVENEPD
     PEDQEIFYPT REWQVVKPGQ AVPAGLHMRL NLQTGKNEAK LLEEKEGKDR PKQKRKSSTT
     SDKYTKKELK EALTKFKEGA EQLSPAEEKD YLQDIKQRFR PIEDLQKAFN DLNINVETDF
     EIMTKIVNRF NSSSSTTEKV SALYDLEYYV HQVDNAQNLL KLGALQLLIN SLNSTDTLLI
     ENSAFVIGSA LSSNPKVQIE AFEAGALQKL LVILAADQEV SVKKKTLYAL SSMLRQFPYA
     QQRFMKLGGL QILKNFFKEK NAESLYIRVI TLLYDMIMEK MLLYKENNTE QYEQKYQQYN
     QINLLESITE QGWCPIISDL LRLPENDSRE KVLKAVLTLI PLCRAEFLKD CNLLTLLNSL
     RKEYEGLAAE ELRSGEQDGY FSEILSLTIS ITDKLK