ID   SILA_SALTM              Reviewed;        1048 AA.
AC   Q9ZHC9;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Putative cation efflux system protein SilA;
GN   Name=silA;
OS   Salmonella typhimurium.
OG   Plasmid pMG101.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90371;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9930866; DOI=10.1038/5545;
RA   Gupta A., Matsui K., Lo J.-F., Silver S.;
RT   "Molecular basis for resistance to silver cations in Salmonella.";
RL   Nat. Med. 5:183-188(1999).
CC   -!- FUNCTION: Component of the sil cation-efflux system that confers
CC       resistance to silver. May be part of a three-component cation/proton
CC       antiporter.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. {ECO:0000305}.
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DR   EMBL; AF067954; AAD11749.1; -; Genomic_DNA.
DR   RefSeq; WP_002436621.1; NZ_JAETZG010000001.1.
DR   AlphaFoldDB; Q9ZHC9; -.
DR   SMR; Q9ZHC9; -.
DR   TCDB; 2.A.6.1.3; the resistance-nodulation-cell division (rnd) superfamily.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 3.30.2090.10; -; 2.
DR   InterPro; IPR027463; AcrB_DN_DC_subdom.
DR   InterPro; IPR001036; Acrflvin-R.
DR   InterPro; IPR004763; CzcA/CusA/SilA/NccA/HelA/CnrA.
DR   PANTHER; PTHR32063; PTHR32063; 1.
DR   Pfam; PF00873; ACR_tran; 1.
DR   PRINTS; PR00702; ACRIFLAVINRP.
DR   SUPFAM; SSF82714; SSF82714; 2.
DR   TIGRFAMs; TIGR00914; 2A0601; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Membrane; Plasmid;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1048
FT                   /note="Putative cation efflux system protein SilA"
FT                   /id="PRO_0000161846"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        446..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        485..505
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        539..559
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        737..757
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        871..891
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        897..917
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        928..948
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        985..1005
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1012..1032
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1048 AA;  114604 MW;  3B624051C5B886F3 CRC64;
     MIEWIIRRSV ANRFLVMMGA LFLSIWGTWT IINTPVDALP DLSDVQVIIK TSYPGQAPQI
     VENQVTYPLT TTMLSVPGAK TVRGFSQFGD SYVYVIFEDG TDLYWARSRV LEYLNQVQGK
     LPAGVSSEIG PDATGVGWIF EYALVDRSGK HDLSELRSLQ DWFLKFELKT IPNVAEVASV
     GGVVKQYQIQ VNPVKLSQYG ISLPEVKQAL ESSNQEAGGS SVEIAEAEYM VRASGYLQSI
     DDFNNIVLKT GENGVPVYLR DVARVQTGPE MRRGIAELNG QGEVAGGVVI LRSGKNARDV
     ITAVRDKLET LKASLPEGVE IVTTYDRSQL IDRAIDNLSS KLLEEFFVVA IVCALFLWHV
     RSALVAIISL PLGLCIAFIV MHFQGLNANI MSLGGIAIAV GAMVDAAIVM IENAHKRLEE
     WDHRHPGEQI DNVTRWKVIT DASVEVGPAL FISLLIITLS FIPIFTLEGQ EGRLFGPLAF
     TKTYSMAGAA ALAIIVIPIL MGFWIRGKIP AETSNPLNRV LIKAYHPLLL RVLHWPKTTL
     LVAALSIFTV VWPLSQVGGE FLPKINEGDL LYMPSTLPGV SPAEAAALLQ TTDKLIKSVP
     EVASVFGKTG KAETATDSAP LEMVETTIQL KPEDQWRPGM TIDKIIDELD RTVRLPGLAN
     LWVPPIRNRI DMLSTGIKSP IGIKVSGTVL SDIDATAQSI EAVAKTVPGV VSVLAERLEG
     GRYIDIDINR EKASRYGMTV GDVQLFVSSA IGGAMVGETV EGVARYPINI RYPQDYRNSP
     QALKQMPILT PMKQQITLGD VADINVVSGP TMLKTENARP ASWIYVDARG RDMVSVVNDI
     KTAISEKVKL RPGTSVAFSG QFELLEHANK KLKLMVPMTV MIIFILLYLA FRRVDEALLI
     LMSLPFALVG GIWFLYWQGF HMSVATGTGF IALAGVAAEF GVVMLMYLRH AIEAHPELSR
     KETFTPEGLD EALYHGAVLR VRPKAMTVAV IIAGLLPILW GTGAGSEVMS RIAAPMIGGM
     ITAPLLSLFI IPAAYKLIWL RRHKKSVS