ID   SILR_SALTM              Reviewed;         228 AA.
AC   Q9ZHD3;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Probable transcriptional regulatory protein SilR;
GN   Name=silR;
OS   Salmonella typhimurium.
OG   Plasmid pMG101.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90371;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9930866; DOI=10.1038/5545;
RA   Gupta A., Matsui K., Lo J.-F., Silver S.;
RT   "Molecular basis for resistance to silver cations in Salmonella.";
RL   Nat. Med. 5:183-188(1999).
CC   -!- FUNCTION: Component of the sil cation-efflux system that confers
CC       resistance to silver. Probable member of a two-component regulatory
CC       system SilS/SilR.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by SilS. {ECO:0000305}.
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DR   EMBL; AF067954; AAD11745.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9ZHD3; -.
DR   SMR; Q9ZHD3; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR006291; PcoR.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   TIGRFAMs; TIGR01387; cztR_silR_copR; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Plasmid; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..228
FT                   /note="Probable transcriptional regulatory protein SilR"
FT                   /id="PRO_0000081224"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        125..225
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   228 AA;  25463 MW;  CAE0EBB5E4082F51 CRC64;
     MKILIVEDDI KTGEYLSKGL TEAGFVVDHA DNGLTGYHLA MTAEYDLVIL DIMLPDVNGW
     DIIRMLRSAG KGMPVLLLTA LGTIEHRVKG LELGADDYLV KPFAFAELLA RVRTLLRRGN
     TMITESQLKV ADLSVDLVSR KVSRAGNRIV LTSKEFSLLE FFIRHQGEVL PRSLIAFFMV
     WVHEFLTADT NAIDVAVKRL RAKIDNDYGT KLNQTVRGVG YMLEIPDA