ID   SILU_RHIPU              Reviewed;          30 AA.
AC   P02885;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   11-DEC-2019, entry version 46.
DE   RecName: Full=Sillucin;
OS   Rhizomucor pusillus.
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Lichtheimiaceae; Rhizomucor.
OX   NCBI_TaxID=4840;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=761621; DOI=10.1016/0014-5793(79)80057-5;
RA   Bradley W.A., Somkuti G.A.;
RT   "The primary structure of sillucin and antimicrobial peptide from Mucor
RT   pusillus.";
RL   FEBS Lett. 97:81-83(1979).
RN   [2]
RP   DISULFIDE BONDS.
RX   PubMed=11294620; DOI=10.1021/bi002229x;
RA   Qi J., Wu J., Somkuti G.A., Watson J.T.;
RT   "Determination of the disulfide structure of sillucin, a highly knotted,
RT   cysteine-rich peptide, by cyanylation/cleavage mass mapping.";
RL   Biochemistry 40:4531-4538(2001).
CC   -!- FUNCTION: Sillucin is an antimicrobial agent produced by the
CC       thermophilic fungus Rhizomucor pusillus in liquid culture; it is
CC       effective against Gram-positive bacteria at the level of RNA
CC       metabolism.
CC   -!- SUBCELLULAR LOCATION: Secreted.
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DR   PIR; A03380; SNUMP.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW   Secreted.
FT   PEPTIDE         1..30
FT                   /note="Sillucin"
FT                   /id="PRO_0000044219"
FT   DISULFID        2..7
FT                   /evidence="ECO:0000269|PubMed:11294620"
FT   DISULFID        12..24
FT                   /evidence="ECO:0000269|PubMed:11294620"
FT   DISULFID        13..30
FT                   /evidence="ECO:0000269|PubMed:11294620"
FT   DISULFID        14..21
FT                   /evidence="ECO:0000269|PubMed:11294620"
SQ   SEQUENCE   30 AA;  3209 MW;  F0F0F067FF2BEC3E CRC64;
     ACLPNSCVSK GCCCGBSGYW CRQCGIKYTC