ID   SIM10_HUMAN             Reviewed;          83 AA.
AC   Q96HG1;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 4.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Small integral membrane protein 10;
GN   Name=SMIM10; Synonyms=CXorf69;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH08642.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; Z83826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC008642; AAH08642.1; ALT_INIT; mRNA.
DR   CCDS; CCDS55502.1; -.
DR   RefSeq; NP_001156910.1; NM_001163438.1.
DR   AlphaFoldDB; Q96HG1; -.
DR   BioMuta; SMIM10; -.
DR   EPD; Q96HG1; -.
DR   jPOST; Q96HG1; -.
DR   MassIVE; Q96HG1; -.
DR   MaxQB; Q96HG1; -.
DR   PaxDb; Q96HG1; -.
DR   PeptideAtlas; Q96HG1; -.
DR   PRIDE; Q96HG1; -.
DR   ProteomicsDB; 76744; -.
DR   DNASU; 644538; -.
DR   Ensembl; ENST00000330288.6; ENSP00000328335.4; ENSG00000184785.6.
DR   GeneID; 644538; -.
DR   KEGG; hsa:644538; -.
DR   MANE-Select; ENST00000330288.6; ENSP00000328335.4; NM_001163438.2; NP_001156910.1.
DR   UCSC; uc011mvs.2; human.
DR   CTD; 644538; -.
DR   DisGeNET; 644538; -.
DR   GeneCards; SMIM10; -.
DR   HGNC; HGNC:41913; SMIM10.
DR   HPA; ENSG00000184785; Low tissue specificity.
DR   neXtProt; NX_Q96HG1; -.
DR   OpenTargets; ENSG00000184785; -.
DR   VEuPathDB; HostDB:ENSG00000184785; -.
DR   eggNOG; ENOG502S7BN; Eukaryota.
DR   GeneTree; ENSGT00390000014547; -.
DR   HOGENOM; CLU_186454_1_0_1; -.
DR   InParanoid; Q96HG1; -.
DR   OMA; KGGLPPC; -.
DR   OrthoDB; 1594007at2759; -.
DR   PhylomeDB; Q96HG1; -.
DR   TreeFam; TF336091; -.
DR   PathwayCommons; Q96HG1; -.
DR   BioGRID-ORCS; 644538; 13 hits in 645 CRISPR screens.
DR   GenomeRNAi; 644538; -.
DR   Pharos; Q96HG1; Tdark.
DR   PRO; PR:Q96HG1; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q96HG1; protein.
DR   Bgee; ENSG00000184785; Expressed in popliteal artery and 114 other tissues.
DR   Genevisible; Q96HG1; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR029367; SMIM10.
DR   PANTHER; PTHR34446; PTHR34446; 1.
DR   Pfam; PF15118; DUF4560; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..83
FT                   /note="Small integral membrane protein 10"
FT                   /id="PRO_0000344238"
FT   TRANSMEM        64..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   83 AA;  9236 MW;  6B2CF12980BFF5E2 CRC64;
     MEALGSGHYV GGSIRSMAAA ALSGLAVRLS RPQGTRGSYG AFCKTLTRTL LTFFDLAWRL
     RKNFFYFYIL ASVILNVHLQ VYI