SIM11_HUMAN
ID SIM11_HUMAN Reviewed; 58 AA.
AC P58511;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Small integral membrane protein 11 {ECO:0000312|HGNC:HGNC:1293};
GN Name=SMIM11 {ECO:0000312|HGNC:HGNC:1293};
GN Synonyms=C21orf51 {ECO:0000312|HGNC:HGNC:1293},
GN FAM165B {ECO:0000312|HGNC:HGNC:1293}, SMIM11A {ECO:0000312|HGNC:HGNC:1293};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11707072; DOI=10.1006/geno.2001.6640;
RA Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S.,
RA Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.;
RT "From PREDs and open reading frames to cDNA isolation: revisiting the human
RT chromosome 21 transcription map.";
RL Genomics 78:46-54(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12036298; DOI=10.1006/geno.2002.6782;
RA Gardiner K., Slavov D., Bechtel L., Davisson M.;
RT "Annotation of human chromosome 21 for relevance to Down syndrome: gene
RT structure and expression analysis.";
RL Genomics 79:833-843(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC P58511; Q12797-6: ASPH; NbExp=3; IntAct=EBI-1051936, EBI-12092171;
CC P58511; Q9HA82: CERS4; NbExp=3; IntAct=EBI-1051936, EBI-2622997;
CC P58511; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-1051936, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in heart, spleen, liver, stomach, muscle,
CC lung, testis, skin, PBL and bone marrow.
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DR EMBL; AY033902; AAK68720.1; -; mRNA.
DR EMBL; AY081144; AAL91138.1; -; mRNA.
DR EMBL; AP000320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP000321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP000322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015596; AAH15596.1; -; mRNA.
DR CCDS; CCDS33550.1; -.
DR RefSeq; NP_001300621.1; NM_001313692.1.
DR RefSeq; NP_478062.1; NM_058182.4.
DR RefSeq; XP_016883692.1; XM_017028203.1.
DR RefSeq; XP_016883693.1; XM_017028204.1.
DR RefSeq; XP_016883694.1; XM_017028205.1.
DR RefSeq; XP_016883886.1; XM_017028397.1.
DR RefSeq; XP_016883887.1; XM_017028398.1.
DR RefSeq; XP_016883888.1; XM_017028399.1.
DR AlphaFoldDB; P58511; -.
DR SMR; P58511; -.
DR BioGRID; 119872; 13.
DR IntAct; P58511; 5.
DR STRING; 9606.ENSP00000382234; -.
DR iPTMnet; P58511; -.
DR PhosphoSitePlus; P58511; -.
DR BioMuta; SMIM11A; -.
DR EPD; P58511; -.
DR jPOST; P58511; -.
DR MassIVE; P58511; -.
DR MaxQB; P58511; -.
DR PaxDb; P58511; -.
DR PeptideAtlas; P58511; -.
DR PRIDE; P58511; -.
DR ProteomicsDB; 57082; -.
DR TopDownProteomics; P58511; -.
DR Antibodypedia; 68567; 2 antibodies from 2 providers.
DR DNASU; 54065; -.
DR Ensembl; ENST00000399292.8; ENSP00000382231.4; ENSG00000205670.12.
DR Ensembl; ENST00000399295.2; ENSP00000382234.2; ENSG00000205670.12.
DR Ensembl; ENST00000474455.1; ENSP00000498771.1; ENSG00000205670.12.
DR Ensembl; ENST00000652570.1; ENSP00000499160.1; ENSG00000205670.12.
DR GeneID; 102723553; -.
DR GeneID; 54065; -.
DR KEGG; hsa:102723553; -.
DR KEGG; hsa:54065; -.
DR MANE-Select; ENST00000399292.8; ENSP00000382231.4; NM_058182.5; NP_478062.1.
DR UCSC; uc002ytu.5; human.
DR CTD; 54065; -.
DR DisGeNET; 54065; -.
DR GeneCards; SMIM11A; -.
DR HGNC; HGNC:1293; SMIM11.
DR HPA; ENSG00000205670; Low tissue specificity.
DR neXtProt; NX_P58511; -.
DR VEuPathDB; HostDB:ENSG00000205670; -.
DR eggNOG; ENOG502SFJD; Eukaryota.
DR GeneTree; ENSGT00640000091610; -.
DR HOGENOM; CLU_196183_0_0_1; -.
DR InParanoid; P58511; -.
DR OMA; MNWKVLD; -.
DR OrthoDB; 1624864at2759; -.
DR PhylomeDB; P58511; -.
DR TreeFam; TF330784; -.
DR PathwayCommons; P58511; -.
DR SignaLink; P58511; -.
DR BioGRID-ORCS; 102723553; 0 hits in 11 CRISPR screens.
DR BioGRID-ORCS; 54065; 9 hits in 711 CRISPR screens.
DR ChiTaRS; SMIM11A; human.
DR Pharos; P58511; Tdark.
DR PRO; PR:P58511; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P58511; protein.
DR Bgee; ENSG00000205670; Expressed in body of stomach and 100 other tissues.
DR Genevisible; P58511; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR042125; SMIM11.
DR PANTHER; PTHR35975; PTHR35975; 1.
DR Pfam; PF14981; FAM165; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..58
FT /note="Small integral membrane protein 11"
FT /id="PRO_0000079517"
FT TRANSMEM 10..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 29..58
FT /evidence="ECO:0000255"
FT VARIANT 51
FT /note="K -> R (in dbSNP:rs34016792)"
FT /id="VAR_054066"
SQ SEQUENCE 58 AA; 6886 MW; 902E0799AD6E5854 CRC64;
MNWKVLEHVP LLLYILAAKT LILCLTFAGV KMYQRKRLEA KQQKLEAERK KQSEKKDN
