SIM11_MOUSE
ID SIM11_MOUSE Reviewed; 55 AA.
AC Q99J19;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Small integral membrane protein 11 {ECO:0000250|UniProtKB:P58511};
GN Name=Smim11 {ECO:0000312|MGI:MGI:1916186};
GN Synonyms=Fam165b, Smim11a {ECO:0000250|UniProtKB:P58511};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Mammary gland;
RX PubMed=11707072; DOI=10.1006/geno.2001.6640;
RA Reymond A., Friedli M., Neergaard Henrichsen C., Chapot F., Deutsch S.,
RA Ucla C., Rossier C., Lyle R., Guipponi M., Antonarakis S.E.;
RT "From PREDs and open reading frames to cDNA isolation: revisiting the human
RT chromosome 21 transcription map.";
RL Genomics 78:46-54(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, heart, kidney, thymus, liver,
CC stomach, muscle, lung, testis, ovary, skin and eye.
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DR EMBL; AY033901; AAK68719.1; -; mRNA.
DR EMBL; AK004538; BAC25086.1; -; mRNA.
DR EMBL; BC005668; AAH05668.1; -; mRNA.
DR CCDS; CCDS37404.1; -.
DR RefSeq; NP_620082.1; NM_138743.2.
DR AlphaFoldDB; Q99J19; -.
DR SMR; Q99J19; -.
DR STRING; 10090.ENSMUSP00000070724; -.
DR iPTMnet; Q99J19; -.
DR PhosphoSitePlus; Q99J19; -.
DR EPD; Q99J19; -.
DR jPOST; Q99J19; -.
DR MaxQB; Q99J19; -.
DR PaxDb; Q99J19; -.
DR PRIDE; Q99J19; -.
DR ProteomicsDB; 257169; -.
DR Ensembl; ENSMUST00000063641; ENSMUSP00000070724; ENSMUSG00000051989.
DR Ensembl; ENSMUST00000118064; ENSMUSP00000113086; ENSMUSG00000051989.
DR GeneID; 68936; -.
DR KEGG; mmu:68936; -.
DR UCSC; uc007zyx.1; mouse.
DR CTD; 54065; -.
DR MGI; MGI:1916186; Smim11.
DR VEuPathDB; HostDB:ENSMUSG00000051989; -.
DR eggNOG; ENOG502SFJD; Eukaryota.
DR GeneTree; ENSGT00640000091610; -.
DR HOGENOM; CLU_196183_0_0_1; -.
DR InParanoid; Q99J19; -.
DR OMA; MNWKVLD; -.
DR OrthoDB; 1624864at2759; -.
DR PhylomeDB; Q99J19; -.
DR TreeFam; TF330784; -.
DR BioGRID-ORCS; 68936; 0 hits in 67 CRISPR screens.
DR ChiTaRS; Smim11; mouse.
DR PRO; PR:Q99J19; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q99J19; protein.
DR Bgee; ENSMUSG00000051989; Expressed in animal zygote and 271 other tissues.
DR Genevisible; Q99J19; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR042125; SMIM11.
DR PANTHER; PTHR35975; PTHR35975; 1.
DR Pfam; PF14981; FAM165; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..55
FT /note="Small integral membrane protein 11"
FT /id="PRO_0000079518"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 34..54
FT /evidence="ECO:0000255"
SQ SEQUENCE 55 AA; 6345 MW; B5990461D9797362 CRC64;
MNWKVLEHVP LLLYILAAKT LILCLAFAGV KMYQRRSLEG KLQAEKRKQS EKKAS
