SIM12_HUMAN
ID SIM12_HUMAN Reviewed; 92 AA.
AC Q96EX1; D3DPR5; Q49AP7; Q52LP9; Q8NCB4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Small integral membrane protein 12;
GN Name=SMIM12; Synonyms=C1orf212;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Lung, Lymph, Testis, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- INTERACTION:
CC Q96EX1; P13473-2: LAMP2; NbExp=3; IntAct=EBI-2874543, EBI-21591415;
CC Q96EX1; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-2874543, EBI-5280197;
CC Q96EX1; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-2874543, EBI-2623095;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMIM12 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH11880.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=AAH73851.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=AAH93838.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=AAI07422.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=AAI12232.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=BAC11246.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=EAX07437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAX07438.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAX07439.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK074853; BAC11246.1; ALT_SEQ; mRNA.
DR EMBL; CH471059; EAX07437.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471059; EAX07438.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH471059; EAX07439.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC011880; AAH11880.2; ALT_SEQ; mRNA.
DR EMBL; BC034598; AAH34598.1; -; mRNA.
DR EMBL; BC073851; AAH73851.2; ALT_SEQ; mRNA.
DR EMBL; BC093838; AAH93838.1; ALT_SEQ; mRNA.
DR EMBL; BC107421; AAI07422.2; ALT_SEQ; mRNA.
DR EMBL; BC112231; AAI12232.1; ALT_SEQ; mRNA.
DR CCDS; CCDS53295.1; -.
DR RefSeq; NP_001158296.1; NM_001164824.1.
DR RefSeq; NP_001158297.1; NM_001164825.1.
DR RefSeq; NP_001307190.1; NM_001320261.1.
DR RefSeq; NP_612437.3; NM_138428.5.
DR RefSeq; XP_005270460.1; XM_005270403.4.
DR RefSeq; XP_011538855.1; XM_011540553.2.
DR RefSeq; XP_011538857.1; XM_011540555.2.
DR RefSeq; XP_016855655.1; XM_017000166.1.
DR AlphaFoldDB; Q96EX1; -.
DR SMR; Q96EX1; -.
DR BioGRID; 125245; 38.
DR IntAct; Q96EX1; 15.
DR MINT; Q96EX1; -.
DR STRING; 9606.ENSP00000428585; -.
DR GlyGen; Q96EX1; 1 site, 1 O-linked glycan (1 site).
DR BioMuta; SMIM12; -.
DR EPD; Q96EX1; -.
DR jPOST; Q96EX1; -.
DR MassIVE; Q96EX1; -.
DR MaxQB; Q96EX1; -.
DR PaxDb; Q96EX1; -.
DR PeptideAtlas; Q96EX1; -.
DR PRIDE; Q96EX1; -.
DR ProteomicsDB; 76460; -.
DR TopDownProteomics; Q96EX1; -.
DR Antibodypedia; 67344; 5 antibodies from 5 providers.
DR DNASU; 113444; -.
DR Ensembl; ENST00000417239.1; ENSP00000428541.1; ENSG00000163866.9.
DR Ensembl; ENST00000423898.1; ENSP00000428984.1; ENSG00000163866.9.
DR Ensembl; ENST00000446026.1; ENSP00000430285.1; ENSG00000163866.9.
DR Ensembl; ENST00000456842.1; ENSP00000430198.1; ENSG00000163866.9.
DR Ensembl; ENST00000521580.3; ENSP00000428585.1; ENSG00000163866.9.
DR GeneID; 113444; -.
DR KEGG; hsa:113444; -.
DR MANE-Select; ENST00000521580.3; ENSP00000428585.1; NM_138428.6; NP_612437.3.
DR UCSC; uc001byb.4; human.
DR CTD; 113444; -.
DR DisGeNET; 113444; -.
DR GeneCards; SMIM12; -.
DR HGNC; HGNC:25154; SMIM12.
DR HPA; ENSG00000163866; Low tissue specificity.
DR neXtProt; NX_Q96EX1; -.
DR OpenTargets; ENSG00000163866; -.
DR VEuPathDB; HostDB:ENSG00000163866; -.
DR eggNOG; ENOG502S2AD; Eukaryota.
DR GeneTree; ENSGT00390000009435; -.
DR HOGENOM; CLU_160787_0_0_1; -.
DR InParanoid; Q96EX1; -.
DR OMA; GMDSTQV; -.
DR OrthoDB; 1641442at2759; -.
DR PhylomeDB; Q96EX1; -.
DR TreeFam; TF328614; -.
DR PathwayCommons; Q96EX1; -.
DR SignaLink; Q96EX1; -.
DR BioGRID-ORCS; 113444; 15 hits in 1076 CRISPR screens.
DR ChiTaRS; SMIM12; human.
DR GenomeRNAi; 113444; -.
DR Pharos; Q96EX1; Tdark.
DR PRO; PR:Q96EX1; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96EX1; protein.
DR Bgee; ENSG00000163866; Expressed in ileal mucosa and 184 other tissues.
DR ExpressionAtlas; Q96EX1; baseline and differential.
DR Genevisible; Q96EX1; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031933; UPF0767.
DR PANTHER; PTHR28599; PTHR28599; 1.
DR Pfam; PF15990; UPF0767; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..92
FT /note="Small integral membrane protein 12"
FT /id="PRO_0000299478"
FT TRANSMEM 15..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 18
FT /note="F -> S (in Ref. 3; AAH34598)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 92 AA; 10799 MW; 0BABF3F953D22B0B CRC64;
MWPVFWTVVR TYAPYVTFPV AFVVGAVGYH LEWFIRGKDP QPVEEEKSIS ERREDRKLDE
LLGKDHTQVV SLKDKLEFAP KAVLNRNRPE KN
