ID   SIM12_MOUSE             Reviewed;          92 AA.
AC   Q78RX3;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Small integral membrane protein 12;
GN   Name=Smim12;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Liver, and Tongue;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SMIM12 family. {ECO:0000305}.
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DR   EMBL; AK075968; BAC36086.1; -; mRNA.
DR   EMBL; AK131915; BAE20870.1; -; mRNA.
DR   EMBL; AK141221; BAE24597.1; -; mRNA.
DR   EMBL; AL626768; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466552; EDL30256.1; -; Genomic_DNA.
DR   EMBL; BC147067; AAI47068.1; -; mRNA.
DR   EMBL; BC147068; AAI47069.1; -; mRNA.
DR   CCDS; CCDS38883.1; -.
DR   RefSeq; NP_084528.1; NM_030252.2.
DR   AlphaFoldDB; Q78RX3; -.
DR   SMR; Q78RX3; -.
DR   STRING; 10090.ENSMUSP00000131941; -.
DR   EPD; Q78RX3; -.
DR   MaxQB; Q78RX3; -.
DR   PaxDb; Q78RX3; -.
DR   PeptideAtlas; Q78RX3; -.
DR   PRIDE; Q78RX3; -.
DR   ProteomicsDB; 261232; -.
DR   Antibodypedia; 67344; 5 antibodies from 5 providers.
DR   DNASU; 80284; -.
DR   Ensembl; ENSMUST00000142029; ENSMUSP00000131941; ENSMUSG00000042380.
DR   GeneID; 80284; -.
DR   KEGG; mmu:80284; -.
DR   UCSC; uc008uuq.1; mouse.
DR   CTD; 113444; -.
DR   MGI; MGI:1933141; Smim12.
DR   VEuPathDB; HostDB:ENSMUSG00000042380; -.
DR   eggNOG; ENOG502S2AD; Eukaryota.
DR   GeneTree; ENSGT00390000009435; -.
DR   HOGENOM; CLU_160787_0_0_1; -.
DR   InParanoid; Q78RX3; -.
DR   OMA; GMDSTQV; -.
DR   OrthoDB; 1641442at2759; -.
DR   PhylomeDB; Q78RX3; -.
DR   TreeFam; TF328614; -.
DR   BioGRID-ORCS; 80284; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Smim12; mouse.
DR   PRO; PR:Q78RX3; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q78RX3; protein.
DR   Bgee; ENSMUSG00000042380; Expressed in interventricular septum and 252 other tissues.
DR   Genevisible; Q78RX3; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031933; UPF0767.
DR   PANTHER; PTHR28599; PTHR28599; 1.
DR   Pfam; PF15990; UPF0767; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..92
FT                   /note="Small integral membrane protein 12"
FT                   /id="PRO_0000414320"
FT   TRANSMEM        15..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   92 AA;  10796 MW;  FAABFA7BFBF746B1 CRC64;
     MWPVLWTVVR TYAPYVTFPV AFVVGAVGYH LEWFIRGKTP QPVEEEKSIL ERREDRKLDE
     MLGKDHTQVV SLKDKLEFAP KAVLNRNRPE KN