SIM12_RAT
ID SIM12_RAT Reviewed; 92 AA.
AC D4ACP2;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Small integral membrane protein 12;
GN Name=Smim12;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMIM12 family. {ECO:0000305}.
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DR EMBL; AABR03040720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH473968; EDL80479.1; -; Genomic_DNA.
DR RefSeq; NP_001263412.1; NM_001276483.1.
DR RefSeq; XP_006238969.1; XM_006238907.3.
DR AlphaFoldDB; D4ACP2; -.
DR SMR; D4ACP2; -.
DR STRING; 10116.ENSRNOP00000019224; -.
DR PaxDb; D4ACP2; -.
DR PeptideAtlas; D4ACP2; -.
DR PRIDE; D4ACP2; -.
DR Ensembl; ENSRNOT00000019224; ENSRNOP00000019224; ENSRNOG00000014352.
DR Ensembl; ENSRNOT00000094142; ENSRNOP00000096325; ENSRNOG00000014352.
DR Ensembl; ENSRNOT00000101473; ENSRNOP00000084740; ENSRNOG00000014352.
DR Ensembl; ENSRNOT00000102125; ENSRNOP00000087108; ENSRNOG00000014352.
DR Ensembl; ENSRNOT00000102383; ENSRNOP00000081715; ENSRNOG00000014352.
DR GeneID; 685634; -.
DR KEGG; rno:685634; -.
DR UCSC; RGD:1591379; rat.
DR CTD; 113444; -.
DR RGD; 1591379; Smim12.
DR eggNOG; ENOG502S2AD; Eukaryota.
DR GeneTree; ENSGT00390000009435; -.
DR HOGENOM; CLU_160787_0_0_1; -.
DR InParanoid; D4ACP2; -.
DR OMA; GMDSTQV; -.
DR OrthoDB; 1641442at2759; -.
DR PhylomeDB; D4ACP2; -.
DR TreeFam; TF328614; -.
DR PRO; PR:D4ACP2; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Proteomes; UP000234681; Chromosome 5.
DR Bgee; ENSRNOG00000014352; Expressed in heart and 19 other tissues.
DR Genevisible; D4ACP2; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031933; UPF0767.
DR PANTHER; PTHR28599; PTHR28599; 1.
DR Pfam; PF15990; UPF0767; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..92
FT /note="Small integral membrane protein 12"
FT /id="PRO_0000414323"
FT TRANSMEM 15..34
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 92 AA; 10809 MW; 4ABBFA7BFBEB2B07 CRC64;
MWPVLWTVVR TYAPYVTFPV AFVVGAVGYH LEWFIRGKDP QPVEEEKSIL ERREDRKLDE
MLGKDHTQVV SLKDKLEFAP KAVLNRNRPE KN
