ID   SIM12_XENTR             Reviewed;          91 AA.
AC   Q28EM2;
DT   14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Small integral membrane protein 12;
GN   Name=smim12; ORFNames=TGas122k06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SMIM12 family. {ECO:0000305}.
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DR   EMBL; CR848175; CAJ83448.1; -; mRNA.
DR   EMBL; AAMC01059955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC161537; AAI61537.1; -; mRNA.
DR   RefSeq; NP_001016019.1; NM_001016019.2.
DR   RefSeq; XP_004911668.1; XM_004911611.3.
DR   RefSeq; XP_017947078.1; XM_018091589.1.
DR   RefSeq; XP_017949361.1; XM_018093872.1.
DR   AlphaFoldDB; Q28EM2; -.
DR   SMR; Q28EM2; -.
DR   STRING; 8364.ENSXETP00000035952; -.
DR   PaxDb; Q28EM2; -.
DR   Ensembl; ENSXETT00000094050; ENSXETP00000067593; ENSXETG00000034553.
DR   Ensembl; ENSXETT00000095799; ENSXETP00000082437; ENSXETG00000039592.
DR   GeneID; 548773; -.
DR   KEGG; xtr:548773; -.
DR   CTD; 113444; -.
DR   Xenbase; XB-GENE-5841153; smim12.
DR   eggNOG; ENOG502S2AD; Eukaryota.
DR   HOGENOM; CLU_160787_0_0_1; -.
DR   InParanoid; Q28EM2; -.
DR   OMA; YITWPIA; -.
DR   OrthoDB; 1641442at2759; -.
DR   PhylomeDB; Q28EM2; -.
DR   TreeFam; TF328614; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000034553; Expressed in ovary and 12 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR031933; UPF0767.
DR   PANTHER; PTHR28599; PTHR28599; 1.
DR   Pfam; PF15990; UPF0767; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..91
FT                   /note="Small integral membrane protein 12"
FT                   /id="PRO_0000414327"
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   91 AA;  10555 MW;  866F86FC2D3B2357 CRC64;
     MWPVLWAAAR TYAPYITFPV AFVVGAVGYQ LEWFIRGTPE QPVEELSILE KREERTLQET
     MGKDVTQVLS LKEKLEFTPK AVLNRNRQEK S