SIM13_HUMAN
ID SIM13_HUMAN Reviewed; 91 AA.
AC P0DJ93; G3V581;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Small integral membrane protein 13;
GN Name=SMIM13; Synonyms=C6orf228;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SMIM13 family. {ECO:0000305}.
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DR EMBL; AL136139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC032356; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS56396.1; -.
DR RefSeq; NP_001129047.1; NM_001135575.1.
DR AlphaFoldDB; P0DJ93; -.
DR SMR; P0DJ93; -.
DR BioGRID; 128747; 2.
DR STRING; 9606.ENSP00000451866; -.
DR iPTMnet; P0DJ93; -.
DR PhosphoSitePlus; P0DJ93; -.
DR BioMuta; SMIM13; -.
DR DMDM; 363579843; -.
DR EPD; P0DJ93; -.
DR jPOST; P0DJ93; -.
DR MassIVE; P0DJ93; -.
DR MaxQB; P0DJ93; -.
DR PaxDb; P0DJ93; -.
DR PeptideAtlas; P0DJ93; -.
DR PRIDE; P0DJ93; -.
DR ProteomicsDB; 52537; -.
DR TopDownProteomics; P0DJ93; -.
DR Antibodypedia; 74351; 5 antibodies from 5 providers.
DR DNASU; 221710; -.
DR Ensembl; ENST00000376935.4; ENSP00000452219.1; ENSG00000224531.6.
DR Ensembl; ENST00000416247.4; ENSP00000451866.1; ENSG00000224531.6.
DR GeneID; 221710; -.
DR KEGG; hsa:221710; -.
DR MANE-Select; ENST00000416247.4; ENSP00000451866.1; NM_001135575.2; NP_001129047.1.
DR UCSC; uc011dio.3; human.
DR CTD; 221710; -.
DR GeneCards; SMIM13; -.
DR HGNC; HGNC:27356; SMIM13.
DR HPA; ENSG00000224531; Tissue enhanced (brain).
DR neXtProt; NX_P0DJ93; -.
DR OpenTargets; ENSG00000224531; -.
DR VEuPathDB; HostDB:ENSG00000224531; -.
DR eggNOG; ENOG502S5IU; Eukaryota.
DR GeneTree; ENSGT00560000078630; -.
DR HOGENOM; CLU_190096_0_0_1; -.
DR InParanoid; P0DJ93; -.
DR OMA; CGWYVVW; -.
DR OrthoDB; 1610660at2759; -.
DR PhylomeDB; P0DJ93; -.
DR PathwayCommons; P0DJ93; -.
DR BioGRID-ORCS; 221710; 12 hits in 1073 CRISPR screens.
DR GenomeRNAi; 221710; -.
DR Pharos; P0DJ93; Tdark.
DR PRO; PR:P0DJ93; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; P0DJ93; protein.
DR Bgee; ENSG00000224531; Expressed in cerebellar vermis and 189 other tissues.
DR Genevisible; P0DJ93; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031851; DUF4750.
DR PANTHER; PTHR36877; PTHR36877; 1.
DR Pfam; PF15938; DUF4750; 1.
PE 3: Inferred from homology;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..91
FT /note="Small integral membrane protein 13"
FT /id="PRO_0000414060"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 47..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..91
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 58
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:E9Q942"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:E9Q942"
FT MOD_RES 62
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:E9Q942"
FT MOD_RES 69
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:E9Q942"
SQ SEQUENCE 91 AA; 10351 MW; 9394704F780C22A7 CRC64;
MWHSVGLTLL VFVATLLIVL LLMVCGWYFV WHLFLSKFKF LRELVGDTGS QEGDHEPSGS
ETEEDTSSSP HRIRSARQRR APADEGHRPL T
