ID   SIM14_HUMAN             Reviewed;          99 AA.
AC   Q96QK8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Small integral membrane protein 14;
GN   Name=SMIM14; Synonyms=C4orf34;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   SUBCELLULAR LOCATION, TOPOLOGY, AND MUTAGENESIS OF 26-LEU-ARG-27 AND
RP   76-ARG-GLY-77.
RX   PubMed=24499674; DOI=10.5483/bmbrep.2014.47.10.252;
RA   Jun M.H., Jun Y.W., Kim K.H., Lee J.A., Jang D.J.;
RT   "Characterization of the cellular localization of C4orf34 as a novel
RT   endoplasmic reticulum resident protein.";
RL   BMB Rep. 47:563-568(2014).
CC   -!- INTERACTION:
CC       Q96QK8; Q969F0: FATE1; NbExp=4; IntAct=EBI-373430, EBI-743099;
CC       Q96QK8; O43765: SGTA; NbExp=3; IntAct=EBI-373430, EBI-347996;
CC       Q96QK8; P03973: SLPI; NbExp=3; IntAct=EBI-373430, EBI-355293;
CC       Q96QK8; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-373430, EBI-5235340;
CC       Q96QK8; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-373430, EBI-12038591;
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000269|PubMed:24499674}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:24499674}.
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DR   EMBL; BC008502; AAH08502.1; -; mRNA.
DR   CCDS; CCDS3456.1; -.
DR   RefSeq; NP_001304825.1; NM_001317896.1.
DR   RefSeq; NP_001304826.1; NM_001317897.1.
DR   RefSeq; NP_777581.1; NM_174921.2.
DR   RefSeq; XP_016863351.1; XM_017007862.1.
DR   RefSeq; XP_016863352.1; XM_017007863.1.
DR   AlphaFoldDB; Q96QK8; -.
DR   BioGRID; 128406; 6.
DR   IntAct; Q96QK8; 6.
DR   MINT; Q96QK8; -.
DR   STRING; 9606.ENSP00000295958; -.
DR   iPTMnet; Q96QK8; -.
DR   PhosphoSitePlus; Q96QK8; -.
DR   BioMuta; SMIM14; -.
DR   DMDM; 74732680; -.
DR   jPOST; Q96QK8; -.
DR   MassIVE; Q96QK8; -.
DR   PaxDb; Q96QK8; -.
DR   PeptideAtlas; Q96QK8; -.
DR   PRIDE; Q96QK8; -.
DR   ProteomicsDB; 77885; -.
DR   Antibodypedia; 54789; 108 antibodies from 14 providers.
DR   DNASU; 201895; -.
DR   Ensembl; ENST00000295958.10; ENSP00000295958.4; ENSG00000163683.12.
DR   GeneID; 201895; -.
DR   KEGG; hsa:201895; -.
DR   MANE-Select; ENST00000295958.10; ENSP00000295958.4; NM_174921.3; NP_777581.1.
DR   UCSC; uc003guo.4; human.
DR   CTD; 201895; -.
DR   DisGeNET; 201895; -.
DR   GeneCards; SMIM14; -.
DR   HGNC; HGNC:27321; SMIM14.
DR   HPA; ENSG00000163683; Tissue enhanced (liver).
DR   neXtProt; NX_Q96QK8; -.
DR   OpenTargets; ENSG00000163683; -.
DR   PharmGKB; PA162379760; -.
DR   VEuPathDB; HostDB:ENSG00000163683; -.
DR   eggNOG; ENOG502S28C; Eukaryota.
DR   GeneTree; ENSGT00390000018294; -.
DR   HOGENOM; CLU_152284_0_0_1; -.
DR   InParanoid; Q96QK8; -.
DR   OMA; RQNQNAC; -.
DR   OrthoDB; 1588274at2759; -.
DR   PhylomeDB; Q96QK8; -.
DR   TreeFam; TF314023; -.
DR   PathwayCommons; Q96QK8; -.
DR   SignaLink; Q96QK8; -.
DR   BioGRID-ORCS; 201895; 10 hits in 1037 CRISPR screens.
DR   ChiTaRS; SMIM14; human.
DR   GenomeRNAi; 201895; -.
DR   Pharos; Q96QK8; Tdark.
DR   PRO; PR:Q96QK8; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q96QK8; protein.
DR   Bgee; ENSG00000163683; Expressed in corpus epididymis and 193 other tissues.
DR   ExpressionAtlas; Q96QK8; baseline and differential.
DR   Genevisible; Q96QK8; HS.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
DR   InterPro; IPR020309; Uncharacterised_CD034/YQF4.
DR   PANTHER; PTHR31019; PTHR31019; 1.
DR   Pfam; PF11027; DUF2615; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..99
FT                   /note="Small integral membrane protein 14"
FT                   /id="PRO_0000268816"
FT   TOPO_DOM        1..49
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..99
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          78..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         26..27
FT                   /note="LR->TN: In N-gly,N; creates a N-glycosylation site."
FT                   /evidence="ECO:0000269|PubMed:24499674"
FT   MUTAGEN         76..77
FT                   /note="RG->TN: In N-gly,C; does not creates a N-
FT                   glycosylation site."
FT                   /evidence="ECO:0000269|PubMed:24499674"
SQ   SEQUENCE   99 AA;  10710 MW;  B0E90C424D2D34EB CRC64;
     MAEGGFDPCE CVCSHEHAMR RLINLLRQSQ SYCTDTECLQ ELPGPSGDNG ISVTMILVAW
     MVIALILFLL RPPNLRGSSL PGKPTSPHNG QDPPAPPVD